Drug discovery > Lead Discovery Products & Reviews

Disruptive technology for the characterization of small molecules and fragments. With enhanced sensitivity, expanded thermal options, and advanced microfluidics, the Carterra Ultra™ platform is our most sensitive instrument for interrogating multiple proteins and off-target binding in parallel.

Disruptive Technology for Screening and Characterization. Enhanced sensitivity and fast data collection rate build upon unmatched capabilities in throughput and enable assays such as TPDs/PROTAC®s, kinase, cytokines, DELs, and protein:protein inhibitors.

Specac’s high-pressure Diamond Compression Cell is designed for in-compartment FTIR spectroscopic transmission analysis and FTIR microscope analysis. Samples are compressed and flattened to a uniform thickness between a pair of diamond windows until the sample is thin enough for the FTIR instrument or microscope beam to penetrate. This type of cell is particularly useful for the analysis of hard samples, including minerals, ru…

The Specac Mini-Film Maker is designed to produce high-quality thin films of polymer and plastic materials for infrared transmission analysis. This product enables quick and easy hot pressing of samples at any temperature between ambient to 250°C, to give constant and reproducible thickness films over the range 50 to 500 microns with a formed diameter of 15mm. The Mini-Film Maker Kit includes the Mini-Film Maker Press with…

Specac offers a Short Pathlength Gas Cell that is ideal for routine gas and vapour spectroscopic analysis at room temperature, low pressures, and static or flow conditions. The cell has a fixed 10 cm pathlength, and is available in Pyrex™ and stainless steel. This Short Pathlength Gas Cell is supplied with a choice of NaCl, KBr, CaF2, BaF2, or ZnSe infrared transmission windows, and is mounted in an optical spectrometer wit…

A silicon ATR consumable technology which helps you zero in on your analysis. Zero cleaning. Zero risk of cross-contamination. Zero hassle.

TSKgel Protein C4 is a reversed phase HPLC column for the separation of intact proteins.

TSKgel mAb SW SEC Columns – Setting new Benchmarks for Antibody Analysis.

TSKgel UP-SW Series offers highest resolution based on established SEC technology.

TOYOPEARL AF-rProtein L affinity resin for the capture of mAbs and mAb fragments 

TOYOPEARL Sulfate-650F offers a high binding capacity for IgG across a range of pH values and conductivities

The TSKgel UP-SW3000-LS UHPLC column analyses biotherapeutics by size exclusion chromatography and is designed for the combination with MALS and MS.

Octave BIO intensifies your downstream processing productivity

SkillPak 50 (2.5 cm ID x 10 cm L, CV 50 mL) and 200 (5 cm ID x 10 cm L, CV 200 mL) pre-packed columns offer a reproducible and efficient solution for developing purification methods for biomolecules. They are the best solution to scale up methods developed on SkillPak 1 and 5 mL pre-packed columns.

The TSKgel ODS-100 HPLC column features a newly developed RP material for the separation of small compounds which is specifically designed to simplify difficult separations.

The AptaFluor® SAH Methyltransferase Assay Kit enables ultra-sensitive, direct detection of SAH—the universal product of methyltransferase reactions—using a riboswitch-based TR-FRET format. With no coupling enzymes required, it delivers high signal-to-background, Z’ ≥ 0.7, and is fully HTS-compatible for drug discovery and inhibitor screening.

BellBrook Labs’ Lead Discovery Services deliver expert support for hit-to-lead efforts. From inhibitor screening and potency profiling to residence-time, mechanism-of-action, and selectivity studies, their team tailors efficient enzymatic assays to your program—accelerating lead advancement with precision and flexibility.

The Transcreener® cGAMP cGAS Assay Kit offers mix-and-read fluorescent detection of cGAMP—the product of cGAS activity—with no coupling enzymes required. Available in FP or TR‑FRET readouts (far-red tracers minimize interference), it’s HTS-ready (Z’ ≥ 0.7), automation-compatible, and validated on 96‑, 384‑, and 1536‑well formats for enzyme kinetics, SAR, and inhibitor screening.

The CD73 activity assay for HTS and hit-to-lead. Measure specific activity of CD73 in a simple mix-and-read format. The kit is designed for compound library screening and follow-up inhibitor discovery.

The Transcreener dAMP Exonuclease Assay directly measures dAMP produced by exonuclease enzymes as they cleave polynucleotides. 

Simplify your workflow and save valuable laboratory time with the fully automated MACS® Sampler, a perfect extension for the MACS® Matchmaker instrument, allowing you to fully integrate automatization solution for your interaction studies.

With the MACS® Matchmaker you can experience a robust platform that delivers quantitative data on binder affinity, kinetics, and specificity in complex samples. Unlock new possibilities in your research today – because every target deserves its perfect match!

PurePlus™ Deep Well Plates 96-well plates are designed for automation, high throughput screening (HTS), or heavy lab use. Each well holds either 1.2 mL or 2.2 mL and has smooth inside surfaces to ensure that all of your samples can be pipetted.

PCR Strip Capping Tool

Countable PCR is the only PCR-based method that directly counts your targets, giving you unprecedented and highly sensitive insights into your samples. Don't be limited by qPCR, dPCR, or even NGS. Find even the rarest targets when you experience single-molecule precision and ultra-high sensitivity in a familiar PCR workflow. Plus – quickly develop a new multiplex assay in 3 days.