Drug discovery > Lead Discovery Products & Reviews

Twist Biopharma, a division of Twist Bioscience, provides services to help accelerate the way our partners discover and optimize antibody therapeutics with our unique DNA writing technology. Twist constructs proprietary antibody libraries precisely designed to match sequences that occur in the human body giving our partners an integral and unbiased resource for antibody therapeutic discovery and optimization.

TSKgel Protein C4 is a reversed phase HPLC column for the separation of intact proteins.

TSKgel mAb SW SEC Columns – Setting new Benchmarks for Antibody Analysis.

TSKgel UP-SW Series offers highest resolution based on established SEC technology.

TOYOPEARL AF-rProtein L affinity resin for the capture of mAbs and mAb fragments 

TOYOPEARL Sulfate-650F offers a high binding capacity for IgG across a range of pH values and conductivities

The TSKgel UP-SW3000-LS UHPLC column analyses biotherapeutics by size exclusion chromatography and is designed for the combination with MALS and MS.

Octave BIO intensifies your downstream processing productivity

SkillPak 50 (2.5 cm ID x 10 cm L, CV 50 mL) and 200 (5 cm ID x 10 cm L, CV 200 mL) pre-packed columns offer a reproducible and efficient solution for developing purification methods for biomolecules. They are the best solution to scale up methods developed on SkillPak 1 and 5 mL pre-packed columns.

The TSKgel ODS-100 HPLC column features a newly developed RP material for the separation of small compounds which is specifically designed to simplify difficult separations.

The AptaFluor® SAH Methyltransferase Assay Kit enables ultra-sensitive, direct detection of SAH—the universal product of methyltransferase reactions—using a riboswitch-based TR-FRET format. With no coupling enzymes required, it delivers high signal-to-background, Z’ ≥ 0.7, and is fully HTS-compatible for drug discovery and inhibitor screening.

BellBrook Labs’ Lead Discovery Services deliver expert support for hit-to-lead efforts. From inhibitor screening and potency profiling to residence-time, mechanism-of-action, and selectivity studies, their team tailors efficient enzymatic assays to your program—accelerating lead advancement with precision and flexibility.

The Transcreener® cGAMP cGAS Assay Kit offers mix-and-read fluorescent detection of cGAMP—the product of cGAS activity—with no coupling enzymes required. Available in FP or TR‑FRET readouts (far-red tracers minimize interference), it’s HTS-ready (Z’ ≥ 0.7), automation-compatible, and validated on 96‑, 384‑, and 1536‑well formats for enzyme kinetics, SAR, and inhibitor screening.

The CD73 activity assay for HTS and hit-to-lead. Measure specific activity of CD73 in a simple mix-and-read format. The kit is designed for compound library screening and follow-up inhibitor discovery.

The Transcreener dAMP Exonuclease Assay directly measures dAMP produced by exonuclease enzymes as they cleave polynucleotides. 

Simplify your workflow and save valuable laboratory time with the fully automated MACS® Sampler, a perfect extension for the MACS® Matchmaker instrument, allowing you to fully integrate automatization solution for your interaction studies.

With the MACS® Matchmaker you can experience a robust platform that delivers quantitative data on binder affinity, kinetics, and specificity in complex samples. Unlock new possibilities in your research today – because every target deserves its perfect match!

PurePlus™ Deep Well Plates 96-well plates are designed for automation, high throughput screening (HTS), or heavy lab use. Each well holds either 1.2 mL or 2.2 mL and has smooth inside surfaces to ensure that all of your samples can be pipetted.

Syft Tracer Pharm11 redefines genotoxic impurities analysis for compliant pharma and CDMO workflows as fast and easy with no sample preparation. This solution includes next-gen SIFT-MS Syft Tracer, a CTC autosampler, a high-throughput (HTP) inlet, and 21 CFR Part 11 compliant software SyftAuditTracer.

Syft SafetySure is a class-leading solution for rapid, reliable detection of hazardous chemicals such as fumigants and volatile toxic industrial chemicals in workplace settings. It provides reproducible identification and quantification of hazardous chemicals commonly found in workplaces such as methyl bromide, sulfuryl fluoride, chloropicrin, ethylene dibromide, ethylene oxide and phosphine. It's simple to use with no consuma…

PCR Strip Capping Tool

Countable PCR is the only PCR-based method that directly counts your targets, giving you unprecedented and highly sensitive insights into your samples. Don't be limited by qPCR, dPCR, or even NGS. Find even the rarest targets when you experience single-molecule precision and ultra-high sensitivity in a familiar PCR workflow. Plus – quickly develop a new multiplex assay in 3 days.

In-depth understanding of complete genome in human, aninal, plant and microbe with end-to-end services.  

Sequencing only service for customer-premade libraries at different read lengths and capacities to suit any cost, project scale and turnaround with the world-leading, powerful, and sophisticated sequencing platforms (Illumina, Pacbio, and Oxford Nanopore). 

16S/18S/ITS rRNA amplicon metagenomic sequencing employs universal primers to target specific regions to identify the phylogeny and taxonomy from complex microbiomes.