Member since: 2016
Organization: University of Pittsburgh
This instrument is very useful
Application Area: Analyzed cardiomyocytes beating rhythm
"I used this instrument to analyze human iPS cell derived cardiomyocytes beating rhythm. This instrument can give you reproducible results if you seed a certain number of cardiomyocytes every time, and the cardiomyocytes quality is stable. The advantage of this instrument is that it can collect real-time data for hours and days, especially if you need to perform drug treatment, it's easy to compare before and after drug treatment. Besides, the software is easy to use."
Member since: 2015
Organization: University of Cologne
Application Area:Cardiac function and Assessment of drug effects on cardiac cells activities
"Ease of Use because it is Label-free, real-time assessment platform, short and long term observations, precise system with ~1 ms resolution. Ease export and data analysis After Sales Care: Easy to manage Value for Money: Expensive for developing country researchers "
Member since: 2015
Application Area:kinase inhibitor cardiotoxicity
"The xCELLigence has provided extremely robust data with experiments I have conducted looking at effects of compounds as well as effect of gene knockdown on CM beating. Technical support staff have always been extremely quick to answer and helpful with any questions I have had. "
The xCELLigence RTCA Cardio instrument monitors cardiomyocyte activity for cardiotoxicity assessment. The contraction-relaxation cycle of cardiomyocytes gives rise to a distinct, rhythmic fluctuation in impedance that is readily captured on the millisecond time scale. Changes in the intensity and periodicity in impedance are monitored in seconds or in days to assess cardiomyocyte contractility and viability in the presence of various drugs.
The xCELLigence RTCA Cardio instrument, which analyzes cells in an electronic 96-well microtiter plate format (E-Plate Cardio 96), is placed in a standard CO2 cell culture incubator and interfaces via a cable with analysis and control units that are housed outside the incubator. User friendly software allows for real-time control and monitoring of the instrument.
For Research Use Only. Not for use in diagnostic procedures.