Vandetanib by STEMCELL Technologies Inc.

Manufacturer STEMCELL Technologies Inc.  |   Model: 73532
Tyrosine kinase inhibitor; Inhibits VEGFR1, KDR, FLT-4, EGFR, FGFR, ABL, RET, and SRC

Vandetanib by STEMCELL Technologies Inc. product image

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Vandetanib is a multi-kinase inhibitor targeting primarily receptor tyrosine kinases, such as vascular endothelial growth factor receptors (VEGFR1, KDR, and FLT4), epidermal growth factor receptor (EGFR), and fibroblast growth factor receptor (FGFR; Morabito et al.). It most potently inhibits KDR with an IC₅₀ of 40 nM. It also inhibits non-receptor tyrosine kinases such as RET, ABL, and SRC as well as several serine/threonine kinases (Carlomagno et al.; Hennequin et al.; Kiselyov et al.; Levinson & Boxer).


  • Inhibits tumor growth in mouse xenograft models, including RET/PTC papillary thyroid carcinoma and lung carcinoma (Hennequin et al.; Carlomagno et al.).
  • Inhibits angiogenesis, cell growth, and metastasis in numerous cancer cell lines (Morabito et al.; Wedge et al.).