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Biotage® Oligo SPE
Solid-phase extraction solution for bioanalysis of therapeutic oligonucleotides
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Biotage® Oligo SPE is a solid-phase extraction (SPE) solution specifically developed for efficient extraction of oligonucleotide-based therapeutics from biological samples, including plasma, serum, urine and tissue homogenates. Using mixed-mode weak anion exchange (WAX) chemistry, Biotage® Oligo SPE effectively removes interfering proteins, salts, sugars, lipids and DNA fragments. Its tailored sorbent design delivers clean extracts and consistently high recoveries across a variety of oligonucleotide structures and chemistries.
Highlights:
- Accurately quantify a wide range of therapeutic oligonucleotides, even at low concentrations
- Effectively removes matrix interferences to deliver cleaner extracts for consistent, high-sensitivity LC-MS/MS analysis.
- Supports robust, high-throughput workflow with seamless integration into automated systems.
- Expert-developed protocols streamline method development and optimization, minimizing oligonucleotide degradation and maximizing analyte recovery from protein binding.
