UltraFAIMS by Owlstone Medical

Manufacturer Owlstone Medical
UltraFAIMS is a chip-based FAIMS (field asymmetric waveform ion mobility spectrometry) platform designed to interface with a Mass Spectrometer to provide additional in-source separation of ions. The core of the ultraFAIMS platform is a microchip-sized FAIMS spectrometer that allows the selective transmission of ions based on differences in the way their mobility varies in a changing electric field. In FAIMS-MS, the FAIMS device is used as a tunable filter, allowing certain ions to be transmitte... Read more


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UltraFAIMS

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UltraFAIMS is a chip-based FAIMS (field asymmetric waveform ion mobility spectrometry) platform designed to interface with a Mass Spectrometer to provide additional in-source separation of ions.

The core of the ultraFAIMS platform is a microchip-sized FAIMS spectrometer that allows the selective transmission of ions based on differences in the way their mobility varies in a changing electric field. In FAIMS-MS, the FAIMS device is used as a tunable filter, allowing certain ions to be transmitted to the mass spectrometer while blocking others. UltraFAIMS extends this through its ability to dynamically change the tuning of the filter at very high speed, enabling real-time separation as well as static filtering.

FAIMS separates ions based on the differences in ion mobility of specific species at strong and weak fields. FAIMS devices selectively transmit ion species by applying an asymmetric high-frequency separation field that causes ions to drift towards the electrodes, and then superimposing a constant compensation field that allows a specific subset of ions to pass through the device. Scanning the compensation field over a range of values produces a spectrum of ions separated by their differential mobilities.


Advantages:

  • Reaching dispersion fields more than twice those possible in conventional FAIMS devices increases the range of analytes that can be separated.
  • The ion transit time through the ultraFAIMS chip is less than 250µs, which is ~100 times faster than transit times through the fastest previous FAIMS devices.
  • Full ultraFAIMS sweeps can be carried out in under a second, allowing real-time LC-FAIMS-MS analysis, even during very short UPLC peaks.
  • Removal of the chip for cleaning or for replacement is quick and easy.
  • The system has a small footprint and requires no additional gas supply, although separation can be enhanced if needed with the use of solvent vapors added to the carrier gas supply.
  • The system can also be set to non-FAIMS mode, allowing all species to be transmitted simultaneously.
  • FAIMS performance is sensitive to the shape of the gap between the electrodes.
  • A chip footprint the size of a US quarter makes integration of the ultraFAIMS chip between the ionisation source and MS inlet much more straightforward.