ultraDAWN™ by Wyatt Technology Corp.

The ultraDAWN real-time multi-angle light scattering (RT-MALS) instrument is a PAT instrument that helps develop and optimize processes for the purification and production of polymers, viral vectors, lipid nanoparticles, proteins, liposomes and similar nanoscale products. 

ultraDAWN measures:

• Molar mass (M_w) of macromolecules
• Radius of gyration (R_g) of macromolecules
• Size of nanoparticles
• Particle concentration of nanoparticles

Based on these measurements and pre-set thresholds, ultraDAWN generates analog or digital triggers to indicate a process endpoint, deviation from product specifications or notification to begin and end collection of purified fractions. The measurements are made either in-line or on-line. 

With ultraDAWN and RT-MALS, critical quality attributes (CQAs) are monitored directly, in real time, for yield and quality enhancement via rapid feedback on relevant product attributes.