Thermo Scientific™ Q Exactive™ HF Hybrid Quadrupole-Orbitrap™ Mass Spectrometer by Thermo Fisher Scientific

Manufacturer Thermo Fisher Scientific  |   Model: IQLAAEGAAPFALGMBFZ  |  Available Worldwide
4.4
/
5.0
  |  4 reviews
Identify and quantify more proteins, peptides, lipids, glycans and small molecules accurately and in less time with the Thermo Scientific™ Q Exactive™ HF hybrid quadrupole-Orbitrap mass spectrometer.


Thermo Scientific™ Q Exactive™ HF Hybrid Quadrupole-Orbitrap™ Mass Spectrometer by Thermo Fisher Scientific product image
Thermo Scientific™ Q Exactive™ HF Hybrid Quadrupole-Orbitrap™ Mass Spectrometer
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Average Rating: 4.4
4 Scientists have reviewed this product

5 out of 5
Ease of use
4 out of 5
After sales service
5 out of 5
Value for money


  • Status:

    Reviewer
  • Member since: 2019

  • Organization: Uppsala University



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
Great instrument with easy handling and high quality results.
Rating: 5.0

  • Application Area: Proteomics and metabolomics

"Orbitrap from Thermo Scientific has a user-friendly design. They developed a fairly un-complicated software to run the machine. It has so far produced very reliable data and we were able to compare our data with different labs. I highly recommend this machine to new users for proteomics and metabolomics. Capturing of high-quality MS data and reflecting also low abundant analytes is an important strength of the instrument."

Review date: 15 Mar 2019 | Thermo Scientific™ Q Exactive™ HF Hybrid Quadrupole-Orbitrap™ Mass Spectrometer
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: King Adbullah University of Science and Technology



  • Ease of use
    4 out of 5
    After sales service
    3 out of 5
    Value for money
    4 out of 5
Reliable instrument, not much can go wrong.
Rating: 3.7

  • Application Area:Proteomics

"Instrument easy to use, good results, instrument calibration is straight forward. Il highly recommend this instrument for day to day running."

Review date: 15 Mar 2019 | Thermo Scientific™ Q Exactive™ HF Hybrid Quadrupole-Orbitrap™ Mass Spectrometer
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: Max Planck Institute for Biology of Ageing



  • Ease of use
    5 out of 5
    After sales service
    3 out of 5
    Value for money
    4 out of 5
Complete, fast, high reproducibility
Rating: 4.0

  • Application Area:Metabolomics

"User friendly. In metabolomic applications it enables the detection and the identification of new compounds."

Review date: 16 Apr 2018 | Thermo Scientific™ Q Exactive™ HF Hybrid Quadrupole-Orbitrap™ Mass Spectrometer
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: IBN RUSHD MEDICAL AND SCIENTIFIC CO.,



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    5 out of 5
Great Instrument
Rating: 4.7

  • Application Area:Drug EFS proteomics chemistry

"I am getting high quality results. Will recommend to others."

Review date: 16 Apr 2018 | Thermo Scientific™ Q Exactive™ HF Hybrid Quadrupole-Orbitrap™ Mass Spectrometer

Advanced quadrupole technology for greater sensitivity and quantitative dynamic range

The Q Exactive HF instrument uses a segmented quadrupole mass filter to achieve more precise precursor isolation for better discrimination between analytes and coeluting interferences. An advanced active beam guide increases ion transmission. The result is superior sensitivity and greater quantitative dynamic range, especially when dealing with complex mixtures.


Multiple, sophisticated modes of data acquisition/quantitation ensure optimum quantitative results

The Q Exactive HF mass spectrometer supports multiple approaches to quantitation including selected ion monitoring (SIM), parallel-reaction monitoring (PRM), and data-independent acquisition (DIA). Users can select the technique best matched to their sample and information requirements.

  • SIM - selected ion monitoring provides simple method setup with maximum selectivity and sensitivity. It is ideal for quantifying small numbers of compound in samples of moderate complexity.
  • PRM - parallel-reaction monitoring provides high selectivity and high sensitivity with confident targeted confirmation. Quantitation is carried out post-acquisition for greater throughput. High-resolution, accurate-mass Orbitrap spectra ensure confident confirmation through library matching.
  • DIA - data independent acquisition enables large-scale targeted proteomics studies with qualitative confirmation. Its simple and universal acquisition set-up does not require detailed sample knowledge prior to data acquisition. DIA increases reproducibility and comprehensiveness with a complete record of quantitative data. It facilitates retrospective analysis of additional analytes.


Ultra-high-field Orbitrap mass analyzer increases resolving power and scan speed for greater productivity and higher confidence in less time

The Q Exactive HF system features a new ultra-high-field Orbitrap mass analyzer that, while physically smaller, provides higher resolution and faster scan speeds. Combined with the inherent superior quality of Orbitrap spectra, the Q Exactive HF system provides more-confident identification and quantitation in less time

  • Scan speed up to 18 Hz result in up to 50% more IDs from shorter gradients
  • Resolving power of up to 240,000 (FWHM) at m/z 200 ensures maximum ID confidence
  • Spectral quality significantly superior to Q-TOF mass spectrometers yields better protein coverage and quantitation results
  • Polarity switching (one full cycle in <1 sec at a resolution setting of 60,000) enables analysis of more, different compounds in a single analysis


Optional intact protein mode for enhanced analysis of intact proteins and protein complexes

When research requires analysis of intact proteins or protein complexes, the Q Exactive HF system can be equipped with an intact protein mode option (available on new instruments only). This option enhances analysis of intact proteins through sophisticated ion beam control and easy pressure adjustment.

Product Overview

Thermo Scientific™ Q Exactive™ HF Hybrid Quadrupole-Orbitrap™ Mass Spectrometer by Thermo Fisher Scientific product image

Thermo Scientific™ Q Exactive™ HF Hybrid Quadrupole-Orbitrap™ Mass Spectrometer

Manufacturer Thermo Fisher Scientific  |  Available Worldwide

4.4 / 5.0 | 4 reviews