A human 3D airway screening platform to identify agents with antiviral activity.
r-Lung-SARS-CoV-2 model
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A human 3D airway screening platform to identify agents with antiviral activity.
This platform is based on zPREDICTA’s tissue reconstruction technology that incorporates the tissue-specific extracellular matrix (ECM) and cellular components to replicate the tissue architecture and its biology outside the human body.
Characteristics of zPREDICTA’s r-Lung-SARS-CoV-2 model:
- Air-liquid interphase (ALI): mimics human airway architecture
- r-Lung ECM: ECM reconstructing the microenvironment of the human alveolar space
- Interstitial ECM: ECM reconstructing the microenvironment of the interstitial space
- Ciliated epithelium: airway cells connected by tight junctions into an epithelial sheet with cilia formed on the apical surface (facing the air compartment); once formed, these ciliated epithelial cells express human ACE2 receptors
- Interstitial fibroblasts: stromal fibroblasts found in the interstitial space
- Inflammatory/immune compartment: immune cells capable of mounting an inflammatory response
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