NEPHELOstar® Plus Microplate Nephelometer
The world’s only laser-based microplate nephelometer

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Great instrument invaluable to our work flows.
Small Molecule Solubility analysis
The Nephelostar is an important part of our workflow for SPR. All compounds are tested for solubility in selected assay buffers before being run through SPR. The Nephelostar has been invaluable in determining whether compounds are soluble/insoluble and hence whether they are suitable for SPR analysis. The Nephelostar is easy to use and quickly gives an indication of the solubility of small molecules.
Review Date: 11 Apr 2022 | BMG LABTECH
The best plate reader and the impeccable after-sales care = BMG
Microalgae and macroalgae cultivation
The Nephelostar plate reader is very effective for my application (follow the growth or biomass estimation of filamentous macroalgae). Once the different parameters are chosen (quite easily than to the very user-friendly interface) your results were really nice and more importantly very reproducible. Honestly, it is so easy to use, probably the best plate reader I ever worked with. That plus the impeccable after-sales care from BMG makes it the perfect tool for my experimentation. In the future, if I could purchase other items/readers from BMG, I would do so without hesitation.
Review Date: 8 Mar 2022 | BMG LABTECH
The NEPHELOstar® Plus
The world’s only laser-based microplate nephelometer
The NEPHELOstar® Plus is BMG LABTECH’s unique light-scattering plate reader. Using forward scattered light, it can measure the solubility or turbidity of a sample in a solution.
NEPHELOstar® Plus Features:
- High-throughput detection compatible with up to 384-well plates
- Increased performance and speed compared to other nephelometers
- Two onboard reagent injectors
The NEPHELOstar® Plus is ideal for applications which include petroleum process control, drug compound solubility, bacterial growth, and precipitation of particles in a solution.
BMG LABTECH’s Atmospheric Control Unit can be added to ensure a proper environmental control within the plate reader. CO2 and O2 can be fully regulated independently.
Accessories
- Atmospheric Control Unit (ACU): provides the ideal environment for cell-based assays by regulating O2 and CO2 gas levels in the microplate reader
- Microplate Stacker: optimises microplate handling and increases throughput by providing rapid loading, unloading, restacking, and continuous feeding for up to 50 microplates
Brochures
NEPHELOstar<sup>®</sup> Plus: Laser-Based Microplate Nephelometer for Light Scattering Detection
The NEPHELOstar Plus is a microplate nephelometer that detects insoluble particles in liquid samples by measuring forward scattered light. Find out about its key features and applications in this brochure.
Microplate Readers Application Note Binder
A book of application notes for all assay needs, using BMG LabTech Microplate Readers. This collection showcases the specific capabilities of the different models from the range of BMG LabTech Microplate Readers available.
Cyclodextrins and Drug Bioavailability - Monitoring Growth of Candida albicans with the NEPHELOstar Microplate Reader
This poster describes the use of laser nephelometry to investigate the effects of complexation on the drug antimycotic activity using BMG LABTECH’s NEPHELOstar.
96-Well Nephelometric Assay to Detect Calcification Propensity of Serum Samples
This application note describes a test that measures the transition from primary to secondary calciprotein particles (CPP) in serum samples. This label-free 96-well plate-based assay measures the conversion of primary to secondary CPP by detecting the changes in laser light scattering associated with it.
Get the best out of your microplate reader
Discover tips and considerations for improving microplate reader measurements. Application specialists, Dr. Ann-Cathrin Volz and Dr. Martin Mangold from BMG LABTECH, discuss the impact of different plate reader parameters on data, and provide empirical evidence of their effect on data quality. They also discuss approaches to optimize microplate reader settings, and share recommendations for using BMG LABTECH's range of microplate readers.
Ultimate Multi-Mode High-Throughput Microplate Readers
Watch this SelectScience.tv interview at Drug Discovery 2009 (ELRIG) to learn more about the world’s only microplate-based nephelometer, NEPHELOstar and the new PHERAstar FS HTS microplate reader. With a built in spectrometer and barcoded optic modules, the PHERAstar FS increases throughput whilst retaining sensitivity.




















