miniDAWN® by Wyatt Technology Corp.

Manufacturer Wyatt Technology Corp.  |   Model: WTREOS  |  Available Worldwide
4.7
/
5.0
  |  42 reviews
The miniDAWN Multi-Angle static Light Scattering (MALS) detector performs absolute characterization of the molar mass and size of macromolecules and nanoparticles in solution, offering superb sensitivity over a wide range of molecular weight, size and concentration.


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miniDAWN®
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Average Rating: 4.7
42 Scientists have reviewed this product

5 out of 5
Ease of use
5 out of 5
After sales service
5 out of 5
Value for money


  • Status:

    Reviewer
  • Member since: 2021

  • Organization: United States Naval Academy



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Reliable data and excellent customer service!
Rating: 5.0

  • Application Area: Polymer characterization

"Really easy to use, and was simple to integrate with my existing HPLC system. The data it produces is extremely reproducible, and the instrument requires little attention which is great. Also, our local Wyatt rep is very accessible for questions that we have and does a great job of answering our questions when they come up. Honestly, one of the best instrument companies I've ever worked with."

Review date: 14 Dec 2021 | miniDAWN®
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: Abbott



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Accurate and reproducible results. Who could ask for more?
Rating: 5.0

  • Application Area:Polymers

"Wyatt Technology and the miniDawn came into my life 20+ years ago. The struggle with polyurethane molecular weights is well known. Lots of techniques and instruments fail to give accurate and reproducible results. With the miniDawn we quickly found the solution. The instrument is easy to use, well supported by the Wyatt team, and most of all gave accurate molar mass and configuration results. What a joy!"

Review date: 14 Dec 2021 | miniDAWN®
  • Status:

    Reviewer

  • Member since: 2020

  • Organization: University of Graz



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Good MALS-detector for SEC, great support!
Rating: 5.0

  • Application Area:Molecular mass Analysis of pharmaceutical proteins

"The miniDAWN is connected to an AGILENT HPLC Infinity 1260 system. We use it as an HPLC detector for our SEC system to analyze the molecular mass of pharmaceutical peptides. HPLC and detector can be controlled by Wyatt's ASTRA software without problems. The software is easy to use and user-friendly, but it is very different from OPENLab from Agilent. The system was explained to me very extensively during the installation and the Supplies for maintenance of the device are very detailed. Questions to Wyatt have always been answered very quickly."

Review date: 14 Dec 2021 | miniDAWN®
  • Status:

    Reviewer

  • Member since: 2021

  • Organization: AllExcel Inc



  • Ease of use
    4 out of 5
    After sales service
    3 out of 5
    Value for money
    4 out of 5
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Overall the instrument is great and gives great results.
Rating: 3.7

  • Application Area:Molecular weight analysis on polymeric samples

"Instrument is easy to use and software is user friendly. Some times I do get some problem with result reproducibility, mostly when the peaks are not sharp or when there is difference between LS and UV peaks. But overall, the instrument is great and worth the value for money."

Review date: 07 Jul 2021 | miniDAWN®
  • Status:

    Reviewer

  • Member since: 2021

  • Organization: Alvogen Inc.



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Excellent accuracy and reproducibility. Awesome after sales support.
Rating: 5.0

  • Application Area:MW determination of sulfated polysaccharides and oligonucleotides

"The detectors from Wyatt produce very accurate and reproducible results. Their after sales support is excellent. I would definitely recommend using their detector line-up."

Review date: 07 Jul 2021 | miniDAWN®
  • Status:

    Reviewer

  • Member since: 2020

  • Organization: Tyndall Formulation Services



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Outstanding instrument quality and customer service.
Rating: 5.0

  • Application Area:Polymer characterization

"I am a long time user of Wyatt instruments. Most recently, my lab acquired a Wyatt Treos (multi-angle light scattering detector) and rEX (refractometer). The installation was complete within a day, and Wyatt provides on-sight training for one scientist with instrument purchase. The multi-day training is comprehensive and highly informative. Customer service is outstanding, with prompt responses to any inquiry. Their instruments and software are top of the line. Strongly recommend this line of equipment for any molecular weight determination and/or size exclusion chromatography detection."

Review date: 09 Jul 2020 | miniDAWN®
  • Status:

    Reviewer

  • Member since: 2020

  • Organization: University of Graz



  • Ease of use
    4 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Good detector for size exclusion with great support.
Rating: 4.7

  • Application Area:Analyze molecular weight of proteins and pharmaceutical additives

"We got this detector alongside an Agilent HPLC system last year. The complete installation and calibration was done by an technician from Wyatt and it has worked very well. The technician gave us a informative introduction to the instrument and was great at answer our questions. We got a lot of additional supplies for mainentance and operating (syringe filters, cleaning material, BSA-Standards and buffer substances for hard checks). The cooperation between Wyatt and Agilent could be better. The control of the HPLC and the miniDAWN works with Wyatt's ASTRA Software, which is easy-to-use and intuitive for results and reports. But on the other hand, control of the HPLC system is partly confusing and a little bit tricky (e.g. the switch-on procedure requires a distinct order of switch on's). Whereas evaluation and creating reports/graphs is easier to handle with ASTRA than with OpenLab CDS Software from Agilent. Results and graphs can be easily be exported to MS Office and the ASTRA software can be installed on other computers without license problems for evaluation and reporting. The miniDAWN itself works as a SEC detector as per description."

Review date: 29 May 2020 | miniDAWN®
  • Status:

    Advanced Reviewer

  • Member since: 2020

  • Organization: Estron Chemical



  • Ease of use
    4 out of 5
    After sales service
    4 out of 5
    Value for money
    4 out of 5
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Great instrument, good software, bad support policy.
Rating: 4.0

  • Application Area:Polymers and small molecules

"Our MiniDAWN runs like a clock and has been a great tool for molecular weight analysis in the lab. I thought the ASTRA software had a relatively steep learning curve, but works fine once the user becomes comfortable."

Review date: 27 May 2020 | miniDAWN®
  • Status:

    Reviewer

  • Member since: 2020

  • Organization: Affimed GmbH



  • Ease of use
    4 out of 5
    After sales service
    5 out of 5
    Value for money
    4 out of 5
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The detector is a great expansion of our SE-HPLC workflow. We don’t want to miss it!
Rating: 4.3

  • Application Area:Analysis of molecular weights and polydispersity of purified protein samples

"Affimed GmbH our vision is to stop cancer from ever derailing patients’ lives. By using our modular and versatile ROCK® (Redirected Optimized Cell Killing) platform, we generate proprietary, next-generation antibodies. Our tetravalent (four binding sites) bispecific (two targets) innate cell engagers are designed to bring innate immune cells (NK cells or macrophages) into proximity to cancer cells and trigger a signal cascade that leads to the destruction of these cancer cells. In consequence, we aim to actualize the next great advancement in IO by creating novel medicines designed to give patients back their innate ability to fight cancer. In my department, we analyze and monitor the assembly of our ROCK® engager formats and therefore screen many different molecular antibody formats on a daily basis. We were looking for a method or an instrument which enables rapid determination of the molecular weight of proteins in their native state at any timepoint in our purification process. We purchased a miniDAWN TreosII two years ago as an expansion of our HPLC system. Today we are mainly using the detector for SEC-MALS analysis which has become one of our standard methods, both for analysis of final protein samples and for in-process controls in terms of molecular weights and polydispersity of the sample. In the meantime we further expanded our system by adding an online Refractive Index Detector (Optilab T-rEX) to increase data accuracy and flexibility of measuring unknown sample components by SEC-MALS."

Review date: 21 Feb 2020 | miniDAWN®
  • Status:

    Reviewer

  • Member since: 2010

  • Organization: Memorial University



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Our group's (thoroughbred) workhorse!
Rating: 5.0

  • Application Area:Synthetic polymer chemistry

"This instrument is used daily by our grad students and researchers to characterize the polymers prepared in our lab. It has given us virtually trouble-free operation for many years now. In the rare event that we needed assistance, the Wyatt service team was excellent and quick. Even after the warranty expired, their help has been fantastic. Also, the LSU training sessions were brilliant, and those alone should make anyone strongly consider purchasing their LS detector from Wyatt."

Review date: 12 Dec 2019 | miniDAWN®


  • Status:

    Reviewer

  • Member since: 2019

  • Organization: Broad Institute



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Very consistent and reproducible data.
Rating: 5.0

  • Application Area:Protein characterization, protein-protein interactions

"The Wyatt system is super user-friendly and provides high-quality data for our applications. The upgraded software is pretty good and the HPLC manager makes it very streamlined."

Review date: 10 Dec 2019 | miniDAWN®
  • Status:

    Reviewer

  • Member since: 2019

  • Organization: Merck



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Great results, can't live without these instruments!
Rating: 5.0

  • Application Area:Protein, polysaccharide, and protein/polysaccharide conjugates

"These instruments are very effective to support analysis on intermediates and drug substances. With these instruments, we have kept achieving high quality and reproducible results. If the users are well trained, these instruments are easy to use and maintain, but highly recommend to follow the procedures of maintenance the vendor suggests, e.g. there are some tricks for cleaning the flow cell. Overall, MALS/RI system is great tool to enable our success in separating large biomolecules and measuring molecular weight and mass."

Review date: 10 Dec 2019 | miniDAWN®
  • Status:

    Reviewer

  • Member since: 2019

  • Organization: Virginia Tech



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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This instrument provides powerful utility to our SEC system.
Rating: 5.0

  • Application Area:Polymer molecular weight and distribution analysis

"The instrument is very easy to use! The touchscreen and ability to control the detector without the need of a separate computer saves time and streamlines the maintenance and care aspect. Any issues that we have had with the system were rapidly resolved by the customer service officials and the local reps."

Review date: 10 Dec 2019 | miniDAWN®
  • Status:

    Reviewer

  • Member since: 2019

  • Organization: The Shepherd Chemical Company



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    4 out of 5
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A fresh perspective in complex chemical characterization.
Rating: 4.3

  • Application Area:Metal carboxylate chemistry

"The miniDawn is a highly efficient instrument which has proven invaluable in characterization of new metal catalysts. The Wyatt team works with you to allow users to expand their knowledge, especially when inventing new specialized chemicals with no references. Sending the instrument to Wyatt for annual calibration is the most cumbersome task but necessary for such high accuracy and precision when analyzing the unknown."

Review date: 10 Dec 2019 | miniDAWN®
  • Status:

    Reviewer

  • Member since: 2016

  • Organization: CNRS, IBCP, Lyon



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Great results! Great system! Great people!
Rating: 5.0

  • Application Area:Study of protein oligomerization

"We have been using the miniDAWN at our institute (IBCP, CNRS, University Lyon, Lyon, France). We have been 100% happy with this machine, providing us with an easy-to use system. The reliability is excellent and the company has been extremely helpful on many occasions."

Review date: 10 Dec 2019 | miniDAWN®
  • Status:

    Reviewer

  • Member since: 2013

  • Organization: Crucell



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Key technology.
Rating: 5.0

  • Application Area:Light scattering

"Next generation technology vital for life sciences."

Review date: 26 Mar 2019 | miniDAWN®
  • Status:

    Reviewer

  • Member since: 2019

  • Organization: Merck



  • Ease of use
    4 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Great innovative product and quality.
Rating: 4.7

  • Application Area:Particle size extrusion and separation

"Great customer service and educational seminars. Dr. Wyatt and his team take time to teach users how to use the unit and self troubleshoot. "

Review date: 26 Mar 2019 | miniDAWN®
  • Status:

    Reviewer

  • Member since: 2019

  • Organization: Merck



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Innovative technology for my assays.
Rating: 5.0

  • Application Area:Molecular weight detection

"Awesome customer service, tailored to our needs, toubleshoot our science, innovative, provide teachings and courses."

Review date: 26 Mar 2019 | miniDAWN®
  • Status:

    Reviewer

  • Member since: 2017

  • Organization: Merck



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Very effective and enables high quality results.
Rating: 5.0

  • Application Area:Saparation of large molecules

"This product is very effective and enables high quality results. It is easy to use. I am more than happy to recommend it to others."

Review date: 17 Jan 2019 | miniDAWN®
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: Pfizer



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    4 out of 5
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An essential part of my routine activities! Fabulous!
Rating: 4.7

  • Application Area:Analysis of different carboxy methyl cellulose and maltose samples

"The MALS detector is one of the champions in determining MW of large molecules, what’s fascinating about it is the fact that it could easily differentiate between 10kDa, 25 kDa, 49 kDa, 90.5 kDa with ease with extremely narrow margin of error. The product was delivered to us seem less was with true professionals, the next day the engineer drop by in our lab and installation was done in a flash. Whenever we encountered slight problems, they would always hear us patiently and delivered solutions over telephone, if not done then they would personally visit and rectify. I would highly recommend this detector."

Review date: 16 Nov 2018 | miniDAWN®
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: Abbvie



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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A much added benefit to typical SEC.
Rating: 5.0

  • Application Area:Analysis of biologic drug candidates.

"The instrument is a must have for analysis of protein therapeutics. It gives a huge advantage to typical analytical SEC when used as SEC-MALS mode because it gives you the absolute molecular weight rather than comparing peaks to a standard. This can help avoid misinterpretation of column interactions as aggregation as well as other common mistakes."

Review date: 06 Nov 2018 | miniDAWN®
  • Status:

    Reviewer

  • Member since: 2016

  • Organization: University of Missouri-Columbia



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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User friendly, broad application, easy to use software, superior customer services
Rating: 5.0

  • Application Area:Analytical chromatography & Protein Purification

"Easy to use software especially if you attend their training classes at Light Scatter University. By far the most superior application to determine molecular weight & oligomeric state of a protein or protein complexes. Customer service respond to your request in a very timely fashion and their excellent professionalism and expertise will be able solve any technical inquires you have."

Review date: 16 Apr 2018 | miniDAWN®
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: CNR



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    5 out of 5
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great results!!
Rating: 4.7

  • Application Area:determination of molecular weight and protein/Protein or protein/DNA interactions

"Reproducible results. Easy to use and a lot of applications in protein/protein interactions"

Review date: 16 Apr 2018 | miniDAWN®
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: KERMEL



  • Ease of use
    4 out of 5
    After sales service
    2 out of 5
    Value for money
    3 out of 5
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Interesting instrument but exploitation of results could be improved
Rating: 3.0

  • Application Area:Analyze polymer

"Instrument used to determine the masses and rg of polymers (polyamide-imide) Easy to use instrument and software but difficulty to exploit the data (method of integration, drift baseline ...) and especially hard to understand the conformation plot, for example"

Review date: 03 Apr 2018 | miniDAWN®
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: University of Utah



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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A must have item in polymer analysis!
Rating: 5.0

  • Application Area:Polymer characterization

"Our biopolymer laboratory has been using Wyatt instruments, including the miniDawn Treos, for many years. This instrument is configured with FPLC/HPLC third party equipment for SEC analysis. The setup of the instrument is straightforward. I consider the miniDawn Treos a great investment as our Wyatt instruments are running almost every day with reproducible results and absolutely no problems. The Wyatt company always offers excellent customer service and technical support which is a must have item in polymer analysis."

Review date: 27 Mar 2018 | miniDAWN®
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: CNR



  • Ease of use
    5 out of 5
    After sales service
    4 out of 5
    Value for money
    4 out of 5
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Great results. I consider this equipment really indispensable in my research
Rating: 4.3

  • Application Area:determination of molecular weight and Protei/Protein/DNA interaction

"Yes, I achieve high quality results and I have many papers in which I obtained results by LS. It is very easy to use."

Review date: 27 Mar 2018 | miniDAWN®
  • Status:

    Reviewer

  • Member since: 2018

  • Organization: Fresenius Kabi Brazil



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Excellent results of analysis.
Rating: 5.0

  • Application Area:HES Starch Analysis

"Excellent equipment. Delivers reproducible and accurate results. Relatively easy operation. Wyatt's support service is quick and attentive."

Review date: 27 Mar 2018 | miniDAWN®
  • Status:

    Reviewer

  • Member since: 2016

  • Organization: Pfenex



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Wonderful Customer Service
Rating: 5.0

  • Application Area:Protein Mw determination

"Our lab uses the Wyatt instruments (TREOS, QELS and rEX) for molecular weight and Rh measurements with our SEC methods. Training included with the instruments is thorough, and the instruments are easy-to-use after LSU. SEC-MALS is an easy way to determine the online Mw/Rh without adding further methods. Wyatt support reps are quick to reply, and thorough with answers. Would definitely recommend."

Review date: 09 Jun 2017 | miniDAWN®
  • Status:

    Reviewer

  • Member since: 2016

  • Organization: CNRS, IBCP, Lyon



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    4 out of 5
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Great results. We could not continue without it.
Rating: 4.7

  • Application Area:Protein science and structural biology.

"My lab has been using this equipment for the past three years. It is so reliable and easy to use that it is used by all the students. We use it to determine the oligomeric states of our proteins and complexes and have obtained spectacular results with it. It has also completely changed our way of looking at size exclusion chromatography. We use for every single project now. Our best purchase."

Review date: 20 Jul 2016 | miniDAWN®
  • Status:

    Reviewer

  • Member since: 2016

  • Organization: Biotec BetaGlucans AS



  • Ease of use
    4 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Very good instrument for the absolute determination of molecular weight in carbohydrate samples
Rating: 4.7

  • Application Area:Analyze carbohydrate samples for average molar mass and mass distribution

"The instrument works very well for the absolute determination of molecular weight of the carbohydrates that we are analyzing, except for the very highest molecular weight fraction (above 10000 kDa). We have some small problems with increasing noise levels over time, which means that the cell needs to be cleaned from time to time, but else that that the setup is working very well. The use of the instrument requires a bit of skill and understanding, but Wyatt's training program does an excellent job in educating the users in this regard. The investment in the miniDAWN TREOS has certainly been a good one for our company."

Review date: 24 Jun 2016 | miniDAWN®
  • Status:

    Reviewer

  • Member since: 2016

  • Organization: Fresenius Kabi Brasil



  • Ease of use
    4 out of 5
    After sales service
    3 out of 5
    Value for money
    4 out of 5
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Good Detector
Rating: 3.7

  • Application Area:Pharmaceutical Industry

"The Detector is very easy to operate. The support is fast and attencious."

Review date: 23 Jun 2016 | miniDAWN®
  • Status:

    Advanced Reviewer

  • Member since: 2016

  • Organization: Ortec, Inc.



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Perfect detector combination for our analytical needs, can't stay in business without them
Rating: 5.0

  • Application Area:Analysis of monomer solutions for the presence or absence of polymer units

"Due to the nature of our materials, no chromophore and not RI sensitive enough, we have employed the miniDawn MALS detector in our process. The development of methods was straight forward, validatable, and reproducible. We have now employed this technique in all of our in-process/finished product testing and in our equipment cleaning procedures. We are so impressed with the instruments and the after sales support of our systems we have just completed the purchase and installation of a second set of instruments, the miniDawn and T-rEX."

Review date: 23 Jun 2016 | miniDAWN®
  • Status:

    Reviewer

  • Member since: 2012

  • Organization: west



  • Ease of use
    3 out of 5
    After sales service
    4 out of 5
    Value for money
    3 out of 5
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The Wyatt treos is great when used in combination with SEC, but not worth the money for batch applications.
Rating: 3.3

  • Application Area:protein stability

"Primary application is to verify molecular weights of proteins and aggregates when coupled to SEC. I think the software is very versatile and easy to use. I found using the instrument in batch mode to be extremely tedious and not very informative. I was disappointed since this application did not measure up to my expectations. I found the instrument easy to use and to calibrate and required little maintenance. Probably the most useful was customer support. The reps I spoke to have always been highly knowledgeable and eager to help. "

Review date: 23 Jun 2016 | miniDAWN®
  • Status:

    Reviewer

  • Member since: 2016

  • Organization: Lifecore Biomedical



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Highly recommended
Rating: 5.0

  • Application Area:Biopolymers

"High quality instrumentation and excellent customer service. Comprehensive service contract helps keep the instrument in excellent running condition for 10+ years of high volume use. Great software - highly refined and user-friendly. Excellent compatibility with third-party equipment."

Review date: 23 Jun 2016 | miniDAWN®
  • Status:

    Reviewer

  • Member since: 2016

  • Organization: adMare Bioinnovations Inc.



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    4 out of 5
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Very useful instrument for our biologic and polymer projects
Rating: 4.7

  • Application Area:molar mass

"Setup and configuration for use is straightforward. easy to maintain, and generated god and reproducible results "

Review date: 23 Jun 2016 | miniDAWN®
  • Status:

    Reviewer

  • Member since: 2016

  • Organization: Vanderbilt University Medical Center



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Provides consistent data that is imperative to my work.
Rating: 5.0

  • Application Area:Polymer size determination

"Easy to use and >5 years later still turning out useful data"

Review date: 23 Jun 2016 | miniDAWN®
  • Status:

    Reviewer

  • Member since: 2016

  • Organization: CNRS



  • Ease of use
    4 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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The instrument to have in a Bio-Physical and Bio-Chemistry lab
Rating: 4.7

  • Application Area:Analyze of protein-conjugate

"This instrument was subtle to use, like for the interpretation of the results but when everything is well understood, all analysis is very clear, reproducible, and verified by other complementary analysis! I strongly recommend this kind of equipment in any Bio-Physical and Bio-Chemistry lab! "

Review date: 23 Jun 2016 | miniDAWN®
  • Status:

    Reviewer

  • Member since: 2016

  • Organization: Regeneron Pharamceuticals



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Great instrument
Rating: 5.0

  • Application Area:Analysis of monoclonal antibodies

"Excellent product that provides consistent results."

Review date: 23 Jun 2016 | miniDAWN®
  • Status:

    Reviewer

  • Member since: 2016

  • Organization: Apicore US LLC



  • Ease of use
    4 out of 5
    After sales service
    3 out of 5
    Value for money
    3 out of 5
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Not easy to operate and interpret the data
Rating: 3.3

  • Application Area:Aanalyse polysaccharide product

"Costly instrument and high cost of service. very difficult to set the method"

Review date: 21 Jun 2016 | miniDAWN®
  • Status:

    Expert Reviewer

  • Member since: 2015

  • Organization: Ajinomoto Althea



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Wonderful instrument, would not hesitate to purchase another.
Rating: 5.0

  • Application Area:Biophysical characterization of proteins

"The miniDAWN TREOS is used in our lab to verify the Mw of our protein projects. The hardware and GUI are simple interfaces, and the Astra software is quite user friendly. Ours has been in service for almost 8 years and still works as if it were brand new. Wyatt continues to provide an unmatched level of support."

Review date: 24 Nov 2015 | miniDAWN®
  • Status:

    Reviewer

  • Member since: 2015

  • Organization: Biomerics



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Rating: 5.0
"I use this product for Mw and Mn testing for polyurethane, PDMS, Elasteon and R&D samples. It does not require calibration, results are absolute and accurate value based on dn/dc value which can be calculated using Wyatt Optilab ReX and Astra software."

Review date: 06 Feb 2015 | miniDAWN®
  • Status:

    Reviewer

  • Member since: 2009

  • Organization: ESSTECH, INC



  • Ease of use
    5 out of 5
    After sales service
    5 out of 5
    Value for money
    5 out of 5
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Rating: 5.0
"This instrument has been a great addition to our lab. the customer support is the best around."

Review date: 19 Apr 2009 | miniDAWN®

The miniDAWN® multi-angle light scattering (MALS) detector connects to most HPLC, GPC, FPLC or FFF separation systems to determine absolute molecular weight, size, and conformation of peptides, proteins, small polymers and nanoparticles, in solution, without reference to calibration standards. 

Eliminate column calibration and idealized assumptions, gain certainty with first-principles MALS analysis. The miniDAWN provides high sensitivity, a wide range of measurement, productivity and versatility second only to that of the DAWN® MALS detector.

Features: 

  • Sensitivity in SEC-MALS mode: 25 ng of 100 kDa polystyrene in THF, or 500 ng of BSA in PBS, using 7.8 x 300 mm SEC columns 
  • Range of molar mass: 200 Da to 10 MDa (may vary with molecular composition or solvent) 
  • Range of rms radius Rg : 10 nm to 50 nm 
  • Integrated ultrasonic cell cleaning module
  • DLS: optional WyattQELS™ embedded dynamic light scattering detector for particle sizes from 0.3 nm to 50 nm (Rh
  • Touch-panel display for immediate access to data, diagnostics and settings
  • Serviceability: fully field-serviceable with extended self-diagnosis of field-replaceable flow cell and hardware modules
  • Software: ASTRA® chromatography software provides comprehensive analyses and user-friendly features including HPLC control, “One-click MW” and user-designed reports. Optional 21CFR11 support for GMP.

Applications:

  • Proteins: absolute molar mass, size and stoichiometry of monomers, oligomers, complexes, aggregates and fragments.
  • Glycoproteins, detergent-solubilized membrane proteins, PEGylated proteins, protein-polysaccharide and protein-DNA complexes; heme-containing proteins that absorb laser light
  • Protein-protein and protein-nucleic acid interactions
  • Polymers: absolute molar mass and size (distributions and moments), conformation, branching and second virial coefficient
  • Linear or branched polymers, co-polymers
  • Nanoparticles: size distributions, structure, encapsulation and concentration of vesicles, dendrimers, small viruses, VLPs, and more
  • Most aqueous and organic solvents