Understanding Antibody and Viral Glycoprotein Interactions Using CG-MALS

This application note describes a method for characterizing the molecular interactions that occur between viral glycoproteins and neutralizing antibodies. Using size-size exclusion chromatography coupled with multi-angle light scattering (SEC-MALS), composition gradient multi-angle light scattering (GC-MALS), miniDAWN TREOS and Wyatt Calypso II we are able understand how the antibody interacts with its antigen in greater detail that was previously known.