Magnis NGS Prep System

Agilent’s automated NGS solutions are accelerating rare disease research at Robert Debré Hospital, Paris. By adopting a single-workflow approach with Agilent advanced automation systems, the hospital is able to process complex samples quickly and accurately, enhancing efficiency and streamlining genomic analysis.

Agilent SureSelect Cancer Custom panels enable tumor genomic profiling with next-generation sequencing (NGS) panels customized to fit specific laboratory requirements, including the incorporation of new and emerging biomarkers. SureSelect Cancer Custom panels are combined with library preparation and target enrichment reagents to enable detection of all key classes of somatic changes, including single nucleotide variants (SNVs), copy number variants (CNVs), insertions/ deletions (indels), and translocations (TLs). Agilent Technologies highlights data demonstrating the high target coverage achieved by SureSelect Cancer Custom panels for assays; and their consistent detection of key somatic variant classes.

Agilent SureSelect cancer tumor-specific assays offer genomic profiling of solid tumors with next-generation sequencing (NGS) panels for lung, colon, pancreas, bladder, and kidney. The panels are comprised of DNA modules of approximately 50 genes each for sequencing on Illumina® MiSeq™ and MiniSeq instruments, enabling tumor genomic profiling at a lower cost. Agilent demonstrates the target coverage and distribution uniformity of the assays, their consistent detection of key somatic variant classes, de novo gene fusion detection from just one gene partner, and variant detection from cell-free DNA (cfDNA) samples.

This white paper from Agilent presents a study in which researchers from the Anatomical Pathology laboratory characterized lung cancer samples using a complete Agilent workflow, reliably detecting variants that are not easily detectable with other systems in a single, DNA-based assay, and increasing reproducibility and lab productivity.

This application note shows the comparison of the performance of manual versus automated library preparation using clinical FFPE and plasma samples containing translocations in ALK, EGFR, ROS1 and other variants.

In this application note, Agilent demonstrates how the MagnisDx NGS Prep system was able to improve the turnaround time of oncology testing by reducing library prep and enrichment processes from two days to nine hours, as well as reducing hands-on time from 2.5 hours to <15 minutes.

Agilent Technologies offers a range of instrumentation to automate your specific workflow needs. Automation has always been a strategic cornerstone for Agilent, but even more now than ever before.

As a trusted industry leader, Agilent is committed to delivering innovative and reliable automated technologies. A distinctive strength of the Agilent team and portfolio lies in the extensive breadth of experience and offerings. The Agilent automation platforms address sample preparation needs for proteins, genomics, cell analysis, and metabolomics workflows.

In this video, Agilent presents the Magnis NGS Prep System and Bravo NGS Platforms, designed to help you generate dependable and high-quality NGS data. These scalable and versatile solutions streamline library preparation and target enrichment, to increase sample capacity without compromising on data quality. By embracing automation, laboratories can improve the end-to-end workflow with integrated hardware and protocols tailored to serve a range of application needs.

This interview was filmed at SLAS2024.