Fluidity One-M
Quantify and characterize any protein interaction
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The Fluidity One-M system enables quantification and characterization of any protein interaction – even in complex backgrounds or with challenging targets.
Fluidity One-M highlights:
- Uses microfluidic diffusional sizing (MDS) technology to measure changes in molecular size (hydrodynamic radius) as binding events occur
- Enables development of customized protocols to study a wide range of interactions – typical run time 35 minutes for 24 datapoints to determine KD
- Eliminates risk of binding artefacts or other surface constraints – measure directly in solution – no surface immobilization
- Minimizes consumption of precious samples – 3.5 μL per datapoint (application dependent), 50-80 μL to determine KD
Accelerate the quantification and characterization of membrane protein interactions for biologically relevant results
Membrane proteins play a crucial physiological role in several processes and thus represent many existing and potential drug targets. It is estimated that ~70% of all FDA-approved drug targets are membrane proteins.
This infographic outlines a 4-step workflow for purification-free affinity and concentration measurement of membrane-protein targets, designed to speed up these breakthroughs in drug discovery. Download your free copy to find out how to minimize your workload to get biologically relevant results and learn more about the innovative Fluidity One-M and microfluidic diffusional sizing technology.
Purification-free affinity and concentration measurement of membrane-protein targets
In this application note, discover an integrated preparative and analytical method that enables researchers to simultaneously measure both the concentration of an endogenous membrane-protein target and its binding affinity to a specific ligand in a native lipid-bilayer environment directly extracted from crude cellular membranes.
In-solution measurement of antibody affinities and binding stoichiometries to neurotoxic amyloid species
Accurate characterization of the interaction between antibodies and aggregate species such as pathogenic oligomeric or fibrillar forms of proteins like α-synuclein (Parkinson’s disease) or A-β peptide (Alzheimer’s disease proves to be challenging for most technologies. Find the solution in this application note by Fluidic Analytics.
Introducing the Fluidity One-M
In this video, discover the Fluidity One-M, a system that uses microfluidic diffusional sizing (MDS) technology to measure changes in molecular size (hydrodynamic radius) enabling the quantification and characterization of protein-interactions.
