Bioanalysis of peptides service
Our industry leading bioanalytical solutions have helped our clients develop new peptide therapeutics to improve the quality of life. Combining our experience and cutting-edge technology, we have has developed and validated methods using LC-MS/MS to quantify levels of peptides in plasma at levels as low as 10 pg/mL.
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Offering high specificity and a wide range of biological targets, peptides have a long history of utilisation as therapeutics. Advances in peptide chemistry have further fuelled growth in this market, resulting in a diverse and complex set of modalities, which we have become experts in offering bioanalytical solutions to our clients using LC-MS/MS technology.
The Development of an LC-MS/MS Assay for Screening Tracheal Aspirate Samples for Pepsin
This application note presents the development of a robust, semi-quantitative LC-MS/MS method to detect pepsin in tracheal aspirate samples for pepsin, and details issues encountered during development and their solutions.
Developing an LC-MS/MS Assay for Screening Tracheal Aspirate Samples for Pepsin
A gastric reflux event (GRE) is defined as the passing of the gastroduodenal contents into the oesophagus and causing damage to the oesophagal mucosa. Monitoring GREs can aid clinical studies for drug development and inform treatment regimes in the clinic to minimise GRE occurrence, which can dramatically improve quality of life. This application note presents the development of a robust, semi-quantitative LC-MS/MS method to detect pepsin in tracheal aspirate using a Waters Acquity hyphenated to a Waters Xevo TQS.
LGC Implements Sensitive Assays to Improve Drug Success
Michael Naughton, Senior Scientist in the Biologicals department within Drug Development Services at LGC, discusses how the company is implementing more sensitive assays to detect low abundance biomarkers and analytes, to meet the needs of the pharmaceutical industry. Hear how the Singulex Erenna® Immunoassay Platform from MilliporeSigma enables sensitive detection of analytes at below endogenous levels, providing a unique insight into health and disease states that can aid early decision making. A case study for IL-6 is presented.
Advances in LC-MS Methods for Quantitation of Drugs and Biomarkers in Biological Matrices
James Howard, Scientist, Bioanalytical Sciences, Drug Development Services at LGC, explains how higher sensitivity in peptide bioanalysis is achieved through supercharging reagent, m-NBA (meta nitrobenzyl alcohol). Watch this video to find out how LGC develop LC-MS methods to overcome the challenges that come with the requirement of high sensitivity.
LGC strengthens presence in reference standards market with acquisition of TRC
The acquisition of Toronto Research Chemicals brings wide breadth of synthetic and analytical chemistry capabilities
11 Experts Share Biomarker Research Insights
We bring you insights, tips and knowledge from 11 experts as they tackle biomarker research using diverse methods
Using LC-MS Approaches to Improve on Traditional Bioanalysis Methods
Learn how the Bioanalysis Department at LGC is implementing LC-MS to improve services
