Alto™ Digital SPR™
Transform biomolecular interaction analysis with Alto™, the world’s first Digital SPR™ system, featuring zero maintenance and cartridge-based characterization from ultra-low sample volumes.
The supplier does not provide quotations for this product through SelectScience. You can search for similar products in our Product Directory.
New generation high throughput SPR.
Drug discovery - Pharma
The better option for SPR in the market, lower price with better throughput and much smaller footprint!
Review Date: 7 Apr 2021 | Nicoya
Transform biomolecular interaction analysis with Alto™, the world’s first Digital SPR™ system, featuring zero maintenance and cartridge-based characterization from ultra-low sample volumes.
The 16-channel Alto accelerates every stage of your research programs with fully automated, label-free analysis of key biomolecular interactions. Powered by Digital Microfluidics for superior liquid handling and nanotechnology-based precision engineering, Alto delivers high-quality kinetic data using just 2 µL of sample. Its maintenance-free, cartridge-based system, intuitive software, and compact design make it accessible for any lab, eliminating the need for dedicated SPR experts. Trusted by over 600 research labs worldwide, Alto is empowering innovation to advance life science research faster and more affordably.
Key features:
- Perform applications such as kinetics, affinity, quantitation, screening, and epitope binning/mapping
- Industry-leading data quality at a fraction of the cost of conventional SPR systems
- Wide range of sample type compatibility, including crude media and serum
- All sample and buffer movements are automated, including serial dilutions
- Full kinetics using 2 μL samples
- Fluidics-free design and zero maintenance
- GxP compliance features available
- API available for integration with automated workcells, plate & liquid handlers
Key applications:
- Kinetics/Affinity Characterization
- Kinetics/Affinity Screening
- Quantitation
- Epitope Mapping/Binning
Designing label-free biosensor assays for Fc receptor binding analysis
Understanding Fc gamma receptor (FcγR) binding kinetics is critical for biotherapeutic development. This application note explores label-free biosensor assays using Alto™ Digital SPR™, highlighting best practices for assay optimization, immobilization strategies, and data analysis to enhance antibody characterization.
A novel icIEF fractionation and SPR-based workflow for correlating the charge structure to the function of a bispecific antibody
This application note introduces an innovative icIEF-SPR workflow for characterizing charge heterogeneity in bispecific antibodies. Using the MauriceFlex system for fractionation and the Alto SPR system for binding analysis, this study highlights the critical role of charge variants in therapeutic development.
Characterization of Fc Gamma Receptor and IgG interactions using Alto
Label-free analysis of biomolecular interactions is critical in the development of biologics, but current analytical instruments are not equipped to meet the needs of the modern biologics researchers. They require substantial amounts of sample and years of experience to produce high-quality data. Alto™, Nicoya’s Digital SPR™ platform, solves these problems through the use of digital microfluidics and integrated LSPR sensors. This application note demonstrates the application of Alto for measuring biomolecular interactions and generating data that is comparable to biolayer interferometry (BLI).
Characterization of biomolecular interactions using Alto
Label-free biomolecular interaction analysis is essential for biologics development, but conventional systems often require large sample volumes, skilled personnel, and complex fluidics prone to reliability issues. Nicoya’s Alto overcomes these challenges with digital microfluidics and integrated LSPR sensors, enabling label-free analysis in sub-microliter droplets. This application note shows that Alto delivers kinetic and affinity results matching a traditional SPR platform, using just 1% of the sample and requiring less than 30 minutes of hands-on time, making it a highly efficient, user-friendly tool for biologics discovery.
Nicoya Lifesciences introduces the Alto GxP Suite to help enhance regulatory compliance for drug development
Discover Nicoya’s Alto GxP Suite, a powerful software expansion for the Alto Digital SPR system, enabling regulated labs to meet FDA 21 CFR Part 11 compliance
Meet the winners of the 2021 Scientists’ Choice Awards for Drug Discovery & Development
Scientific, technological and communications excellence has been celebrated at the Drug Discovery & Development Webinar Series, with Waters, BioTek and PHCbi among those recognized
