Agilent 1260 Infinity II Prime LC System
The 1260 Infinity II Prime LC is a versatile HPLC offering the highest functionality and operational convenience for analytical HPLC and entry-level quaternary UHPLC at pressures up to 800 bar and for flow rates up to 5 mL/min. This versatile HPLC system is a perfect front end for your MS system.
1260 Infinity II Prime LC System
Including a 1260 Infinity II Vialsampler
With InfinityLab Benchtop
Receive your quote directly from the manufacturer.
Robust and efficient equipment
Food Additives (Synthetic colours)
Several applications in food testing including food additives, processing contaminants, vitamins, aflatoxins, and quality-related tests.
Review Date: 26 May 2022 | Agilent Technologies
Robust and efficient equipment
Food Additives (Synthetic colours)
Several applications in food testing including food additives, processing contaminants, vitamins, aflatoxins, and quality-related tests.
Review Date: 26 May 2022 | Agilent Technologies
Perfect Lab Companion
biopharma
The product has the advantages of simple use, good after-sales service, wide application range and strong stability
Review Date: 16 May 2022 | Agilent Technologies
It delivers highly reproducible result with high quality
Bioseparation
1260 Infinity II Prime Bio LC with buffer advisor software greatly simplifies mobile phase preparation and helps us to improve productivity of method development, and robustness of system reduces down-time significantly - it is easy of use for method development and routine testing.
Review Date: 15 May 2022 | Agilent Technologies
Great results
Life science
Good product
Review Date: 15 May 2022 | Agilent Technologies
Great result, eliminate method variabilities and save time!
biopharma applications, esp. oligonucleotide, mRNA, gene editing
1260 Infinity II Prime Bio LC System is an innovative Bio-compatible and Bio-INERT LC. All the surface of tubes and components that will contact with mobile phase and sample are bio-inert, which means best recovery of biological compounds, esp. nucleotide, oligonucleotide and mRNA. These compounds are headache for LC analysts, normally with peak non-specific adsorption, tailing and low recovery for preparative purposes.
Review Date: 15 May 2022 | Agilent Technologies
Faster than conventional one and easy to use with blend-assist and ISET
Convenient and reliable analysis of antibody drug conjugates
Like ISET and Blend -assist functions. They really helps time-consuming in busy works.
Review Date: 12 May 2022 | Agilent Technologies
Yes!
Aminoacid separation
Really a robust equipment, great reproducibility
Review Date: 3 May 2022 | Agilent Technologies
Easy to use and low maintenance costs. Win-win
R&D
Easy to use software and intuitive design. Repairs can also be made easily in-house as well
Review Date: 3 May 2022 | Agilent Technologies
Good machine. I like it.
Carbonyl compounds analysis
It works well, easy to use, and stable. Currently I use it as a HPLC for carbonyl analysis, and thinking to transfer to UHPLC that this LC system is capable to handle.
Review Date: 18 Nov 2020 | Agilent Technologies
The 1260 Infinity II Prime LC is a versatile HPLC offering the highest functionality and operational convenience for analytical HPLC and entry-level quaternary UHPLC at pressures up to 800 bar and for flow rates up to 5 mL/min. This versatile HPLC system is a perfect front end for your MS system.
The 1260 Infinity II Prime LC has gradient and mixing performance equivalent to a 1260 binary system, provides quaternary and ternary solvent mixing, and offers functions like intelligent system emulation technology (ISET) for perfect method transfer. BlendAssist enables automatic mobile phase blending by using 1290 Infinity II Flexible Pump technology.
Features:
- Offers ultimate gradient and mixing performance equivalent to a 1260 binary system and provides quaternary and ternary solvent mixing. Combines the best of the two worlds of 1260 quaternary and 1260 binary systems with good accuracy and precision for flow rates up to 5 mL/min within a pressure range up to 800 bar
- Seamless transfer of methods between LCs regardless of the brand, facilitated by proprietary Agilent Intelligent System Emulation Technology (ISET) as part of the pump, delivering unchanged retention time and peak resolution
- Simplify your workflow: The pump driver-based feature BlendAssist delivers accurately buffer/additive blending without manual interaction
- Reduce the need for manual interaction: With the Multipurpose valve built into the 1260 Infinity II Flexible Pump, you can purge your instrument via software
- Ultralow carryover: The multiwash capability of the new 800 bar-rated 1260 Infinity II Multisampler cleans all relevant injection parts between runs. This sophisticated, integrated feature flushes the injection needle outside with three solvents, and uses seat backflush procedures to reduce carryover to less than 10 ppm
- Efficient sample handling and logistics: Using shallow microplate drawers, the 1260 Infinity II Multisampler takes a maximum load of 16 microtiter plates and up to 6,144 samples - the most of any single system
- Efficient column handling and temperature control: The 1260 Infinity II Multicolumn Thermostat holds up to four columns with direct access to each column through a InfinityLab Quick Change switching valve, eliminating the need to disconnect and reconnect columns
- Improved flexibility: Set up your LC system to suit the way you work, with the InfinityLab Benchtop shelving system
- Stay at your desk: With the new InfinityLab LC Companion local user interface, you can access and control your instrument comfortably from your office or other locations
- Perfect front-end for everyday MS analysis: Performing like a high-pressure mixing system and offering convenient features to get to the optimum results faster
Sensitive detection of low-level byproducts in a small molecule reaction by the Agilent 1260 Infinity II Prime online LC/MS system
In the production process of modern small-molecule pharmaceuticals, it is of crucial importance not only to control the educts and products through the course of the reaction, but also the possibly occurring impurities. Such impurities can pollute the valuable active pharmaceutical ingredient (API). This would make it necessary to introduce additional costly purification steps into the production. This application note demonstrates the online monitoring of a chemical reaction with an occurring byproduct by means of the Agilent 1260 Infinity II Prime Online LC/MS system, including a mass spectrometer, the Agilent LC/MSD iQ single quadrupole. The inclusion of the MSD iQ offers additional sensitivity and selectivity for the identification of low-level impurities for more reliable control of chemical reactions.
Agilent 1260 Infinity II Prime LC with ISET
Agilent Intelligent System Emulation Technology (ISET) facilitates seamless transfer of analytical methods from conventional LC systems such as the Agilent 1200 Series Quaternary LC to the Agilent 1260 Infinity II Prime LC. This Application Note demonstrates the benefit of ISET for the analysis of five antihistaminic drugs. Download it using the button below to find out how HPLC and ISET benefit each other to create a deeper analysis.
Improving return on investment with smart, integrated InfinityLab solutions
In this application note, Agilent demonstrates the economic value of the Agilent 1260 Infinity II Prime LC and the InfinityLab LC/MSD iQ. Download the full note below to explore how these systems are designed to streamline LC workflows in analytical labs and simplify the daily life of operators, resulting in reduced failure rates, increased throughput, and improved overall financial performance.
The LC handbook: A guide to LC columns and method development
In this downloadable handbook, Agilent Technologies presents a guide to choosing LC columns, including tips and tricks to make your job easier and more productive. The guide covers the main columns used in LC, with particular emphasis on reversed-phase high performance liquid chromatography.
Seamless Method Transfer from a Waters Alliance LC to an Agilent 1260 Infinity II Prime LC using ISET
This Application Note by Agilent demonstrates the straightforward transfer of an analytical method from the Waters Alliance 2695 LC to a 1260 Infinity II Prime LC by using ISET.
Improving return on investment in liquid chromatography with the InfinityLab LC Series
This white paper from Agilent illustrates how the new capabilities of the 1260 Infinity II Prime LC can sum up to over 80,000 USD of incremental economic value per year compared to a conventional LC system.
Emulation of a Waters Alliance LC for the analysis of metoclopramide and its impurities
Instrument-to-instrument method transfer is a crucial topic for many different industries, particularly for the regulated pharmaceutical industry. Agilent Intelligent System Emulation Technology (ISET) facilitates the seamless transfer of analytical methods from conventional LC systems to an Agilent UHPLC system. This Application Note demonstrates the straightforward transfer of an analytical method from the Waters Alliance 2695 LC to a 1260 Infinity II Prime LC by using ISET. Metoclopramide and its impurities were analyzed on both systems. Retention times and resolution of the different experiments were evaluated and compared.
Fast optimization and simplified variation of solvent composition using Blend Assist
The Agilent 1260 Infinity II Flexible Pump with Blend Assist can be used to vary buffer or modifier concentration using ternary or quaternary gradients. In this technical note, Blend Assist is used for two different approaches.
1260 Infinity II Prime LC with BlendAssist
Tired of manually mixing mobile phase? The Agilent 1260 Infinity II Prime LC with BlendAssist software enables you to reduce manual interaction during method development. Watch this short video to learn more.
1260 Infinity II Prime LC with ISET
Tired of dedicating methods to LC instruments? With the Agilent 1260 Infinity II Prime LC and Intelligent System Emulation Technology (ISET) you can run methods from your older Agilent, Waters, or Shimadzu LC systems without disruption.
All you need to know about HPLC columns in under an hour
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