The 1260 Infinity II Evaporative Light Scattering Detector (ELSD), although targeted at analytical scale, can also be used with a flow splitter for preparative chromatography applications. It is highly recommended for compounds with little or no UV chromophore, since the detector technique evaporates the solvent and then measures the intensity of the scattered light, which is directly proportional to the sample concentration.
There is no need to make any corrections for composition: the response is independent of any optical properties. Whatever temperature and gas flow rate is selected, the detector rapidly stabilizes and can be used within minutes. There is no baseline drift to consider, baseline integration is straightforward, and reproducibility is excellent. The detector can be programmed and controlled by many available LC software packages.