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5-Azacytidine by STEMCELL Technologies Inc.

Manufacturer STEMCELL Technologies Inc.  |   Model: 72012
Epigenetic modifier; Inhibits DNA methyltransferase (DNMT)
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5-Azacytidine

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5-Azacytidine is an analog of the nucleoside cytidine which can be incorporated into DNA and RNA. 5-Azacytidine acts as an epigenetic modifier by incorporating into DNA where it irreversibly binds to DNA methyltransferases, thus inhibiting their activity.

REPROGRAMMING

  • Increases reprogramming efficiency of mouse fibroblasts to induced pluripotent stem (iPS) cells by inducing full reprogramming of partially reprogrammed cells (Mikkelsen et al.).
  • Resets epigenetic memory in mouse iPS cells, in combination with Trichostatin A (Kim et al.).

DIFFERENTIATION

  • Enhances differentiation to cardiomyocytes from human embryonic stem cells (Yoon et al.).

CANCER RESEARCH

  • Wide range of anti-metabolic activities when tested against cultured cancer cells and an effective chemotherapeutic agent for acute myelogenous leukemia

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