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XcytoMatic® 40 High-throughput cell density analyzer

The XcytoMatic® 40 (XM40™) is a high-throughput cell density and viability analyzer that can run 24 samples in under 14 minutes. The variation between cell counts for these samples is under 3%. If scale-out and scale-up is a concern, you can trust each XM40™ instrument in your production to deliver the same quality results.

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Average Rating 5.0

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The XM40 is fast and easy to use.

 

Average Rating 5.0

Application Area:

Cell counting, hybridoma-cells, WB-cells and cell lines.

The XM40 instrument is very easy to use. It is very fast and the cell count information is very use full. It's easy to change buffers and waste containers on the instrument.

Review Date: 21 Jan 2026 | ChemoMetec

The XcytoMatic® 40 (XM40) is a high-throughput cell density and viability analyzer that can run 24 samples in under 14 minutes. The variation between cell counts for these samples is under 3%. If scale-out and scale-up is a concern, you can trust each XM40 instrument in your production to deliver the same quality results. The instrument-to-instrument variation for this model lies under 5%, supporting easy tech transfer.

We designed the XM40 to support cGMP manufacturing of biologics, vaccines, and advanced therapies by minimizing the required sample volume to just 50 µl, increasing the dynamic cell counting range to 100 million cells per milliliter, and allowing for 100 samples to be analyzed per hour.

New to this line of instruments, we added a brightfield channel – without trypan blue. Combined with fluorescence microscopy, the AI-powered XM-View software accurately tracks cellular debris buildup in your culture. It additionally measures cell diameter, providing added information about cell health.

This instrument reduces the use of consumables, with long-lasting rinsing and staining solutions – all handled automatically by the instrument. All you need to do is plug-and-play. Let the XM40 take care of the rest.

Key features:

  • Fast processing time (~100 samples/hour)
  • Highest cell counting range yet: up to 100 million cells/ml
  • Consistent results across instruments, users and laboratories
  • Brightfield and fluorescent microscopy (trypan blue-free)
  • 21 CFR Part 11/GMP-ready software

Introducing the XcytoMatic 40 Cell Counter

This video introduces the XcytoMatic® 40, a revolutionary cell counter designed for enhanced laboratory efficiency. Discover how this advanced instrument offers unparalleled speed, simplicity, and consistency in cell counting workflows. With its innovative design and intelligent software, the XM40 provides precise, real-time analysis for diverse cell types, simplifying complex procedures and reducing variability.


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