SFC 80/200/350 Preparative Systems
Waters' suite of bulk-scale supercritical fluid chromatography (SFC) purification systems offers the optimal system for the amount of sample you need to purify. These systems easily allow you to purify a large amount of one sample. When faster and more cost-effective means sustainable business operations, SFC is the purification technique that makes the difference. Preparative-scale SFC 80, 200, and 350 systems are automated s…
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A great alternative to HPLC.
Review Date: 22 Aug 2011 | Waters
Waters' suite of bulk-scale supercritical fluid chromatography (SFC) purification systems offers the optimal system for the amount of sample you need to purify. These systems easily allow you to purify a large amount of one sample. When faster and more cost-effective means sustainable business operations, SFC is the purification technique that makes the difference.
Preparative-scale SFC 80, 200, and 350 systems are automated systems that features co-solvent gradient, high pressure separators for quantitative recovery of purified products, such as enantiomers, complex synthetic chemicals and natural products. They are designed for chiral and achiral separations.
Features:
- High pressure CO2 pump
- High pressure co-solvent pump
- Injection module
- UV-Vis detector
- Fraction collection module
- Automated Back Pressure Regulator (ABPR)
- SuperChrom software
Isolating Trace Impurities for Structural Elucidation in a Commercial Fungicide Formulation Using Preparative SFC
Trace impurities in synthetic products that interact with human end users or may have an undesirable environmental fate are regulated by various government agencies such as FDA and EPA. As a result, impurity separation and their structural identification are important research functions for many industries, including pharmaceutical, agrochemical, food, and consumer products. This application note describes a workflow to achieve full structural elucidation of trace impurities that can be implemented using preparative supercritical fluid chromatography to isolate trace impurities.
Facilitating Chiral Method Development Using UPSFC/MS
Chirality plays a critical role in drug profiles because enantiomers can have vastly different biological/pharmacological/toxicological properties. Chiral analysis is typically addressed in the early stage of drug discovery. Due to its superior resolving power and high speed, SFC has gained a strong foothold in the chiral analysis arena. Furthermore, SFC eliminates the use of toxic solvents typically associated with normal phase LC chiral analysis, such as hexane and chloroform.
The use of MS detection was demonstrated to facilitate chiral UPSFC method development. Taking advantage of the specificity of MS detection, a mixture of two enantiomers with different molecular masses was screened simultaneously. By examining the XICs combined with a prior knowledge of the compound mass, the compound identity was easily determined. The throughput for chiral method development was, therefore, improved two-fold, compared to a traditional SFC-UV approach. The ACQUITY UPSFC/MS System is ideal for laboratories pursuing high throughput enantioselective analyses, enantiomeric excess determination in a complex mixture or matrix, and impurity profiling.
