PlasmaQuant MS

The determination of trace elements in human samples is a crucial method in medical diagnostics, commonly analyzing whole blood, serum, plasma, and urine for various elements. Essential trace elements like copper, zinc, selenium, and iodine serve as biomarkers for diagnosing diseases, while toxic elements such as lead, chromium, cadmium, nickel, and mercury are monitored for occupational exposure. Inductively coupled plasma-mass spectrometry (ICP-MS) is preferred for its multi-element capability, high sensitivity, and efficiency. According to EU regulation (EU) 2017/746 on in vitro diagnostic medical devices (IVDR), medical laboratories must use certified kits for these analyses, with in-house developed tests permitted only when no certified kit is available. AnalytikJena discusses using a CE and IVDR-ready kit for trace element analysis in serum and plasma by ICP-MS/MS with the PlasmaQuant MS ICP-MS, demonstrating its effectiveness in accurately determining low elemental concentrations with minimal sample preparation.

In this application note, Analytik Jena demonstrates the robust and sensitive determination of metal and metalloid profiles in four certified reference materials with the PlasmaQuant MS Q, showing its exemplary capability for routine analysis of filter dusts in emission testing labs.

In this application note, find out how the PlasmaQuant® MS enables fast and precise high-throughput analysis of 21 elements in drinking water according to U.S. EPA 200.8.

This application note describes a gradient method for the PQ LC HPLC system developed to separate five arsenic species with special attention to well separated chromatographic signals in shortest time. To test the method‘s applicability for real samples, commercially available apple juice and orange juice samples were analyzed.

The fast, multi-element capability and wide dynamic range of Inductively Coupled Plasma – Mass Spectrometry (ICP-MS), makes it the technique of choice when it comes to elemental analysis of biological materials including urine, whole blood, plasma and serum. This application note describes a study that demonstrates that alkali dilution of biological materials of a clinical nature is an effective sample preparation procedure for multi-element analysis by ICP-MS.

Inductively coupled plasma mass spectrometry (ICP-MS) is now a well-established technique for use in human studies because it can determine both the total elemental content and isotopic ratios with sufficient precision and accuracy in a single analytical run. This application note presents a method for the preparation and determination of Fe isotope ratios in 11 human whole blood sample by ICP-MS with the precision and accuracy to clearly distinguish between female and male samples.

Fe isotopic analysis by ICP-MS is a real analytical challenge because of the numerous and severe isobaric and polyatomic interferences on the four stable isotopes. This study combines the techniques of cool plasma and collision/reaction cell to completely eliminate polyatomic interferences and achieve the necessary precision and accuracy in the determination of Fe isotopes to distinguish between male and female whole blood samples.

This article discusses the comparison of three sample preparation techniques for the analysis of biological solutions, with an emphasis on whole blood. The study involved preparing and analyzing various plasma, serum, urine and whole blood control standards, and determining the concentration of various elements in each matrix from a single, external calibration.

Fresh drinking water is needed for life as well as being a valuable source of vital minerals for health. ICP-MS has become the technique of choice for the monitoring of drinking waters. This application note demonstrates that the PlasmaQuant® MS provides fast and accurate analysis for monitoring the quality of drinking water. The advancement of sample introduction accessories reduces analysis times to less than 1.5 minutes while iCRC technology eliminates problematic interferences quickly and without compromise.

Mercury is a neurotoxin which rapidly bioaccumulates, leading it to be considered as one of the top ten chemicals of public health concern by the World Health Organization. Recent regulations set out in the EU Water Framework Directive define the maximum allowable concentration (MAC) for mercury as 0.05 µg/L. This application note describes how the PlasmaQuant® MS can be optimized for detection of these ultra-trace levels of mercury.

In this video, learn about the PlasmaQuant MS series from Analytik Jena, designed with the modern laboratory in mind to provide faster and more sensitive ICP-MS analysis, for applications from food analysis to biopharma.

This interview was filmed as part of our coverage of Pittcon 2019 - see other video highlights here >>

Dwindling resources and increasing demand for valuable metals illustrates the importance of the technologies used to assist in ensuring a sustainable circular economy

Analytik Jena aims to provide the most optimal solutions for the most requested industrial applications

SelectScience editors report on the new technology taking the limelight at the 2019 Pittcon conference & expo - the conference’s 70th year running

Discover the application notes, scientific posters and compendiums being downloaded daily by clinical scientists

Analytik Jena extends its portfolio with a new ICP-MS

Prepare for the American Society for Mass Spectrometry(ASMS) Annual Meeting by discovering the many applications of mass spectrometry – from pesticide detection to imaging for cancer therapy

Analytic Jena’s PlasmaQuant® MS allows measurement of more than 75 elements