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microOptilab™ Refractive Index Detector for UHPLC

Waters | Wyatt TechnologyWUTREXAvailable: Worldwide

Universal detection for UHPLC and µSEC-MALS.

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Average Rating 4.5

|2Scientists have reviewed this product

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Ease of use


Average Rating 4.0

Application Area:

Sample Analysis

Great detector

Review Date: 13 May 2024 | Waters | Wyatt Technology

Amazing instrument, critical to Analytical chemistry!


Average Rating 5.0

Application Area:

MW determination of monoclonal antibodies

The product is amazing and provides detailed analytical demonstration that is critical to analytical chemistry in a biopharmaceutical environment. It is a reliable source of information that delivers excellent and consistent results. The software and instrument are easy to use and always provide the best results.

Review Date: 23 Jun 2016 | Waters | Wyatt Technology

The microOptilab™ differential refractive index (dRI) detector is specifically designed for use with any UHPLC system. It works alone as a universal concentration detector, or in combination with the µDAWN™multi-angle light scattering (MALS) detector to measure absolute molar mass and size of macromolecules and nanoparticles in solution, via µSEC-MALS.

Considering the extremely small peak volumes of UHPLC, band broadening in the microOptilab™ is kept to the absolute minimum, at less than 4 µL, as compared to 20-40 µL or more from other dRI detectors.


  • dRI noise: 1.5x10-9 RIU
  • dRI range: ±4.7x10-3 RIU
  • Dynamic range: 6,000,000:1
  • Absolute RI sensitivity: ±0.002 RIU
  • Absolute RI range: 1.2 – 1.8 RIU
  • Temperature control: heated/cooled 4 - 65°C, including active stabilization—even at room temperature
  • Wavelength: 660 nm, matched to the µDAWN™; other wavelengths available
  • Touch-panel display for immediate access to data, diagnostics and settings


  • Universal online concentration measurement for chromatography, especially µSEC-MALS for absolute molecular weight
  • Analysis of conjugated proteins, co-polymers and nanoparticle-encapsulated drugs/proteins/DNA/RNA when combined with a MALS and UV detector

Product Overview