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Characterization of PLGA Using SEC-MALS-VIS

23 Jan 2017

In this application note, two commercially available samples were analyzed by SEC coupled to a Multi-Angle Light Scattering (MALS) detector (HELEOS), a refractive index detector (Optilab rEX), and a viscosity (VIS) detector (ViscoStar). The results demonstrate that SEC-MALS-VIS is an excellent method for the characterization of PLGA polyesters as it has the ability to determine not only the molar mass distribution, but to reveal subtle differences in PLGA’s molecular structure.

DAWN™

Waters | Wyatt Technology

The DAWN is the premier Multi-Angle static Light Scattering (MALS) detector for absolute characterization of the molar mass and size of macromolecules and nanoparticles in solution, offering the highest sensitivity and widest range of molecular weight, size, concentration and optional features.

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Characterization of PLGA Using SEC-MALS-VIS