Maurice
Maurice: your workhorse station for purity, identity and heterogeneity analysis
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Amazing instrument
Analysis of antibodies
This instrument is so much easier to use and maintain compared to previous ICE systems. Cartridges last longer, semi automated sample prep, easy instrument cleaning, easy to train new analysts. FLR detection and on board mixing are a huge bonus for consistent sample preparation. Highly recommend it.
Review Date: 1 Oct 2021 | Bio-Techne
Recommend that you purchase at least one in your lab especially for routine CE work.
Therapeutic protein characterization
The product is easy to use for scientist who are not CE experts. The price is moderate but the pice of consumables is high. Because it is almost plug and play, there is less flexibility for method development but there are significant on-line literature resources from the Protein Simple website. Direct support is good but the response can be a little slow. The instrument is productive so the Maurice is worth the price.
Review Date: 15 Jul 2020 | Bio-Techne
Great, I recommend it.
Protein characterization
Yes, this is very easy to use, quite quick in analysis and shows good reproducibility with data.
Review Date: 18 Feb 2019 | Bio-Techne
Reproducible results; High throughput.
Analyze protein for their isoelectric point
I have been using this instrument for almost a year for analyzing proteins and antibodies. The results that Maurice produces are reproducible. The procedure is relatively easy and fast. It is high throughput and comes with a sample tray temperature controller which is a great feature when running too many samples. The cleaning is automated and you can walk away after starting your sequence. The consumables are quite expensive but the price is worth it when valuable results are produced. The customer service is not the best in terms of communication but will get back to you finally with a solution.
Review Date: 30 Nov 2018 | Bio-Techne
Maurice innovates the conventional capillary electrophoresis technology to automate your protein profiling either by size or charge. Need cIEF and CE-SDS data for your mAbs, ADCs, vaccines or virus-like particles? Maurice does it all. Just pop in one of the preassembled cartridges, drop in your sample vials or a 96-well plate, and hit start. You will complete method development in a day; and get high-resolution, reproducible data in minutes.
Application of Maurice CE-SDS for Biopharmaceutical QC Workflows
In this application note, Maurice™ CE-SDS is evaluated on assay performance and method validation characteristics that are important for QC analytical testing using three reference molecules. Bio-Techne demonstrates the application of Maurice CE-SDS to a QC-specific workflow that eliminates the use of a commercial IS, thereby removing potential concerns such as introducing contaminants to test samples and interfering with subsequent analyses.
Comparing SDS-PAGE with Maurice CE-SDS for protein purity analysis
In this application note, Bio-Techne demonstrates how to improve your protein purity characterization with Maurice. The Maurice promises to offer significantly higher peak profile resolution with more accurate quantitation of impurities than other traditional SDS-PAGE slab-gel methods.
Analysis of Monoclonal Antibodies with Carboxypeptidase B
The heavy chain of human IgG contains a C-terminal lysine residue which is typically cleaved off by carboxypeptidase in vivo. For decades, it was believed that the C-terminal clipping of lysine residues did not affect antibody structure and function, and was therefore not considered a critical quality attribute (CQA). However, the significance of C-terminal lysine clipping is just now being recognized, with a recent study demonstrating that antibodies that retain the C-terminal lysine are attenuated for complement-dependent cytotoxicity. Thus, assessing C-terminal lysine variants is required in monoclonal antibody (mAb) process development.
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