Immunosuppressants Concentrated LC-MS Kit
Receive your quote directly from the manufacturer.
Intended Use
This Immunosuppressants kit is intended for the determination of four Immunosuppressant medications in whole blood, conducted by laboratory professionals on LC-MS/MS.
The kits are available in 2 versions: Starter Kit and Solvent Kit.
Summary
Immunosuppressant drugs suppress the immune response in humans. The most common immunosuppressants are the calcineurine inhibitors Cyclosporin and Tacrolimus, and the mTOR inhibitors Sirolimus and Everolimus.
Mass spectrometry based methods have been tested for the determination of Immunosuppressants. In this analytical method, 4 immunosuppressants are determined from human whole blood by LC-MS/MS. Prior to the LC-MS/MS analysis, a sample clean-up is performed to remove the sample matrix and to spike the samples with the internal standard. The prepared samples are injected into the UHPLC system and, after separation by chromatography on an analytical C18 column, the compounds are ionized by electrospray ionization (ESI) and detected by MS/MS.
An isotopic version of the measurand, dissolved in a deproteinization solution. Used to identify and correct potential deviating values, due to errors or varying circumstances in sample preparation or within the LC-MS/MS. The deproteinization solution furthermore deproteinizes the sample to prevent pollution in the LC-MS/MS.
Starter Kit
This Kit includes everything necessary for a first installation of the Immunosuppressants LC-MS/MS kit on an LC-MS/MS system. Includes all solvents for HPLC and sample extraction, Calibrators, Controls, as well as one HPLC column and consumables.
- Regulatory Status: RUO
- Kit size: 300
- Method: LC-MS
- LC-MS run time: 4 min
- Specimen / Volumes: 50 µL Whole blood.
Solvent Kit
The Solvent Kit includes a set of solvents to perform the sample extraction and the HPLC. Calibrators, Controls, Consumables, or an HPLC-Column are not included.
All components can be ordered separately.
- Regulatory Status: RUO
- Kit size: 300
- Method: LC-MS
- LC-MS run time: 4 min
- Specimen / Volumes: 50 µL Whole blood.
Manufactured by Diagnotix; Distributed by Tecan, IBL International GmbH.
