ICON NMR

Bruker offers all you need for quantitative magnetic resonance. From academic, to pharma, to chemical and advanced materials users, we make you successful by enhancing your productivity and expanding the range of NMR and EPR applications.

This application note demonstrates the capabilities of multiphase NMR in providing molecular analyses of complex heterogeneous samples. Typical analytical approaches to environmental research rely on sample processing, such as extractions that provide only a selective window into the true natural state. The integration of concepts from different fields of NMR spectroscopy enables us to produce a novel comprehensive approach that can be used to study and differentiate between the various phases in a heterogeneous sample as well as identify the key structures and their molecular interactions within each phase.

Recording all required NMR experiments for a protein structure calculation, dynamic analysis or even backbone assignment can be very time consuming. This application note explains how by using a combination of different techniques for data acquisition and processing, the time required to record almost all experimental data needed to characterize a protein can be shortened significantly.

This application note demonstrates the suitability of nuclear magnetic resonance (NMR) for the unequivocal structural identification of illegal drugs and legal highs. The article demonstrates how DOSY experiments can be used along with computer-aided structure elucidation of the various compounds that make up synthetic drugs such as China White. It also shows how the structural information obtained can be used to streamline the identification and quantification of compounds present in recreational drug substances through the use of library search and matching tools.

In toxicology studies, alterations to the intrinsic in vivo biochemical profile of an animal can be monitored via NMR spectroscopic analysis of urine. Chemometric processing of the NMR data can enhance understanding of the toxic effects and this application note describes how examination of the principal component analysis (PCA) scores can provide insight into this data in a time-efficient manner.