GenCRISPR™ Cas Nuclease Protein Products and Services (RUO and GMP)

Explore the most comprehensive Cas protein and next-generation Base editor and Prime editor portfolio. Cas9 variants including clicnially validated WT Cas9, low-off-target high fidelity eSpCas9, GFP Cas9 for cell tracking, saCas9 small size for in vivo packaing, and D10A Nickase for single-strand cleavage and higher accuracy when used together with dual gRNA.
Cas12a (formerly Cpf1) is a Class 2 Type V CRISPR-Cas protein used for precise genome editing and nucleic acid detection. Explore best-in-market multispecific editing efficiency with optimized ErCas12a-3NLS, and WT Cas12a and AsCas12a for T-rich genome editing. Cas13a nucleases are Class 2 Type VI CRISPR-Cas enzyme that acts as an RNA-guided, RNA-targeting ribonuclease. Upon recognizing its target RNA, Cas13a activates a unique "collateral cleavage" mechanism, which is harnessed for ultra-sensitive, programmable molecular diagnostics.
Beyond nuclease-based editing, base editors and prime editors enable precise genome modifications without introducing double-strand breaks (DSB). Base editors typically fuse a catalytically impaired Cas protein like D10A Nickase with a deaminase to achieve targeted single-base conversions (e.g., C→T or A→G). Prime editors combine a nickase Cas with a reverse transcriptase and a prime editing guide RNA (pegRNA) to install a broader range of edits, including substitutions, insertions, and deletions, with reduced reliance on donor templates. These next-generation editors improve editing accuracy by minimizing double-strand break–associated errors such as indels and chromosomal rearrangements, enabling more predictable outcomes.