Products & ReviewLife Sciences
Immune Checkpoint Proteins
A focused set of recombinant immune regulatory proteins, such as PD-1, PD-L1, and CTLA-4, essential for research and drug discovery in cancer immunotherapy and autoimmunity.
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Immune checkpoint proteins are regulators of the immune system that can suppress T-cell responses. Tumors often exploit these pathways to evade immune destruction. This product line provides the key reagents needed to develop and test checkpoint inhibitor antibodies and other immunomodulatory drugs.
Key Features & Benefits:
- Includes Key Targets like PD-1/PD-L1, CTLA-4, LAG-3, TIM-3
- High-Affinity Binding to Validated Antibodies
- Functional Grade for Cell-Based Assays
- Available as Monomers or Multimers to Mimic Cell Surface Presentation
Relevant Applications:
- Checkpoint Inhibitor Antibody Screening and Validation
- Binding Kinetics Analysis (e.g., SPR, BLI)
- T-cell Activation and Exhaustion Studies<br> • Companion Diagnostic Development
