CHIPP™
Chaotrope-induced protein precipitation & proteome profiling (CHIPP™) is a readily scalable, label-free assay for the study of drug: target interactions.
Receive your quote directly from the manufacturer.
This novel technology, developed in-house by the scientific team at Momentum Biotechnologies, leverages isothermal, reversible chemical denaturation of proteins to enable sensitive drug target identification under near-physiological conditions with proteome-wide readout (>8,000 proteins). Magnetic particle-based precipitation facilitates increased experimental throughput (96-well plate format) and is compatible with a wide range of downstream workflows.
This robust and automated approach is well-suited for use as a front-line validation assay for primary screening hits, enabling the systematic analysis of drugs and compounds in a fast and reliable way. CHIPP™ demonstrates a high success rate for target identification across a wide range of compounds, including allosteric inhibitors, molecular glues, PROTACs, and enzyme inhibitors.
Applications of CHIPP™ for drug discovery and development include:
- Target identification and deconvolution
- Affinity and selectivity profiling
- Target engagement
Additional applications to support degrader development include:
- Analysis of ternary complex formation
- Target and off-target profiling
