Scaling target deconvolution with CHIPP

This resource introduces CHIPP™, a mass spectrometry‑based approach for target identification and deconvolution in drug discovery. The technique uses chaotrope‑induced protein precipitation to assess changes in protein stability upon drug binding, enabling label‑free detection of drug–target interactions under near‑physiological conditions.

Designed for scalability and automation, CHIPP can be performed in high‑throughput formats, supporting the analysis of large compound libraries and integration into early discovery workflows. Discover how the method has been applied to study diverse modalities, including enzyme inhibitors and targeted degraders, offering a sensitive and efficient solution for proteome‑wide profiling and target confirmation.