ACQUITY UPSFC System
Introducing the ACQUITY UPSFC System Built on the Waters proven UPLC platform that revolutionized the industry by introducing sub-2-µm particle chemistry, this game-changing UPSFC solution enables you to confidently conduct normal-phase chromatographic separations— including chiral and achiral applications. Using carbon dioxide rather than toxic solvents as the main mobile phase, you can now minimize harmful waste while gainin…
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Introducing the ACQUITY UPSFC System
Built on the Waters proven UPLC platform that revolutionized the industry by introducing sub-2-µm particle chemistry, this game-changing UPSFC solution enables you to confidently conduct normal-phase chromatographic separations— including chiral and achiral applications. Using carbon dioxide rather than toxic solvents as the main mobile phase, you can now minimize harmful waste while gaining superior sensitivity, resolution, and speed.
Analysis of Genotoxic Impurities of Imatinib Mesylate by LC-MS from Early Development to Routine Monitoring
This application note describes a sensitive and rapid UPLC method, coupled with mass detection, for the quantitative determination of two genotoxic impurities of the Imatinib mesylate drug substance.
Facilitating Chiral Method Development Using UPSFC/MS
Chirality plays a critical role in drug profiles because enantiomers can have vastly different biological/pharmacological/toxicological properties. Chiral analysis is typically addressed in the early stage of drug discovery. Due to its superior resolving power and high speed, SFC has gained a strong foothold in the chiral analysis arena. Furthermore, SFC eliminates the use of toxic solvents typically associated with normal phase LC chiral analysis, such as hexane and chloroform.
The use of MS detection was demonstrated to facilitate chiral UPSFC method development. Taking advantage of the specificity of MS detection, a mixture of two enantiomers with different molecular masses was screened simultaneously. By examining the XICs combined with a prior knowledge of the compound mass, the compound identity was easily determined. The throughput for chiral method development was, therefore, improved two-fold, compared to a traditional SFC-UV approach. The ACQUITY UPSFC/MS System is ideal for laboratories pursuing high throughput enantioselective analyses, enantiomeric excess determination in a complex mixture or matrix, and impurity profiling.
Introducing the New ACQUITY UPSFC System
Watch this video to learn about the new ACQUITY UPSFC System. Built on Waters’ proven UPLC platform that revolutionised the industry by introducing sub-2-µm particle chemistry, this UPSFC solution enables you to confidently conduct normal-phase chromatographic separations— including chiral and achiral applications. Using carbon dioxide rather than toxic solvents as the main mobile phase, you can now minimize harmful waste while gaining superior sensitivity, resolution, and speed.
New ACQUITY UPSFC System: A Green Alternative to Normal Phase HPLC
In this video from Pittcon 2011, Waters introduce the new ACQUITY UPSFC System for ultra performance SFC. Primary applications of the system include chiral analysis and normal phase replacement. It offers an environmentally friendly, fast and high efficiency alternative to normal phase HPLC. Also learn about Waters' Biopharmaceutical System Solution with new UNIFI software, combining UPLC with high resolution MS to streamline biopharmaceutical workflows.
