940 Professional IC Vario

In this white paper, Metrohm explains the benefits of IC-MS over IC in certain cases, the hyphenation of IC and different MS systems, as well as related norms and standards.

In this white paper, Metrohm explains the benefits of using this hyphenated technique for the accurate measurement of HAAs in potable water.

Food and beverage analysis is challenging due to the large number of analytes and complex matrices, and to meet stringent quality regulations and labeling requirements, fast, robust, and reliable food analysis is a must.

In this application eBook, we outline how you can bring your food and beverage analysis to the next level – enhancing productivity, reducing costs, and achieving accurate results – with simple, streamlined methods that overcome the analytical challenges facing the modern QC lab.

In this application eBook, we cover:

• The benefits of choosing ion chromatography for your food and beverage analysis
• The applications of ion chromatography across the food and beverage sector
• How to achieve compliant testing in your lab
• The different detection techniques including conductivity, UV/vis detection, and amperometry

Crystal clear, clinically pure, no bacteria and no particles: this would be an ideal sample for ion chromatography. The real world is often different. Apart from the ions to be determined, the samples contain matrix components which may be aggressive or lead to precipitation in the system. They can sometimes make analysis difficult, if not impossible. Samples with a high load of matrix components can damage the separation column or lead to blockages in the system. That is why suitable sample preparation is essential for reliable and accurate analysis.

Chloride and sulfate are common impurities present in drug substances and drug products. Limit tests are based on turbidity and/or visual comparison methods as per USP general chapter. These methods lack specificity and data integrity. One of the main goals of the USP monograph modernization initiative is to replace non-specific methods with highly selective and sensitive instrumental analysis methods. We propose a selective and sensitive ion chromatography (IC) method for chloride and sulfate detection in drug substances, potassium carbonate and potassium bicarbonate. The proposed method can be used for other anionic impurities, such as fluoride, bromide, nitrate and nitrate, if needed.

Ion Chromatography Mass Spectrometry (IC-MS) is a powerful tool to handle many challenging analytical tasks. Ion chromatography tackles difficult separation problems of various ionic species and typically works with conductivity detection. Mass detection as a secondary independent detector, confirms the identity of analytes in difficult matrices to ensure correct results. Even co-eluting components can be quantified and detection limits are considerably improved. Various ions, such as nitrate, phosphate, perchlorate, thiosulfate or thiocyanate are reliably separated and detected. Difficult matrices like soil or explosion residues can be removed with automated sample preparation techniques (e.g. with Inline Ultrafiltration or Dialysis). The technique is a robust and easy-to-use way to monitor anions and oxoanions in various matrices, e.g. in environmental, post-explosion and semiconductor samples.

The broad-spectrum herbicide glyphosate is a suspected carcinogen which has led to limit values for glyphosate in drinking water being imposed in many countries. This white paper details separation of glyphosate and AMPA (a metabolite of glyphosate) in the Metrosep Carb 2 separation column using an Ion Chromatography (IC) system consisting of a 940 Professional IC Vario ONE with pulsed amperometric detection (flexIPAD). This method detects very low concentrations and is reliable and inexpensive in comparison to HPLC (High Performance Liquid Chromatography).

This application note briefly describes how the determination of chlorite, bromate and the standard anions in drinking water using a microbore column Metrosep A Supp 5 - 250/2.0 followed by conductivity detection after sequential suppression.

Sodium metabisulfite or pyrosulfite is used as preservative and antioxidant in pharmaceutical products. In water metabisulfite is not stable and is rapidly converted to sulfite. This Application Note describes the determination of metabisulfite as sulfite in an ointment using the 940 Professional IC Vario from Metrohm. The ointment is dissolved in an aqueous solution containing formaldehyde to prevent sulfite from further oxidation.

Brighteners are added to electroplating baths to improve the brightness of the final surface. The brightener concentration needs to be kept constant to maintain the plating quality. This application note describes the IC part of a simultaneous determination of a brightener by IC and CVS (cyclic voltammetric stripping).

Hear Joseane Maria Bulow, Laboratory Manager, describe how the team at BioAgri manages the analysis of over 1000 environmental samples per day, from all areas of Brazil. Hear about the sample management process in her lab, the different analytical techniques used and how automation facilitates the work. SelectScience Interview for ‘Science in Brazil’ Special Feature. Please note this video has English subtitles.