Editorial Article: Virtual Biopharma Summit 2021: Poster highlights

This year's Virtual Biopharma Summit saw a range of fascinating and insightful scientific posters presenting the latest research in biopharma. Discover the hot topics in our top picks below to gain insights on a range of research fields, including pulsed electromagnetic targeting of magnetic nanoparticles as anti-tumor therapy, a novel, commercially viable E. coli expression system, 3D iPSC-derived muscle models, nanoparticle-based strategies to combat covid-19, and more!

Enabling improved bioprocessing solutions with Optimer^®

Current protein-based affinity ligands are unable to resolve a range of complex protein purification problems. This poster describes several commercial case studies where Optimer^® ligands are enabling solutions to these bioprocessing challenges. Download now to discover how Optimer^® ligands enable new therapeutic modalities, and improved yields and cost-of-goods.

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Effect of cysteine mutations on the function of the mitochondrial form of the peroxide sensor Gpx3

Gpx3 is one of the most important antioxidants in yeast and it has a homologous Gpx4 in mammals. In this poster, Balka and Tokatlidis describe their work on the effect of cysteine mutations on the function of Gpx3 in S. cerevisiae. Download now to learn their findings on the viability of mutant Gpx3 variants and their role in H₂O₂ sensitivity.

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Role of nanocarrier-based inhalation L-type calcium channel modulators with antioxidant role to support cardiac myocyte

In India, over 80% of cardiovascular disease (CVD) deaths result from ischemic heart disease and stroke. Here, Radhakrishnan et al., describe their study aiming to develop nanoparticle-based inhalational L-type calcium channel modulators to support the failing cardiac myocyte. Download now to discover how the study provides proof of concept for an innovative, safe, and efficient personalized inhalational medicine for a failing heart that is designed to prevent the progression of heart failure.

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Novel biomarker quantification method using ³¹P NMR for monitoring of cell metabolism

Nuclear magnetic resonance (NMR) spectroscopy is a promising process analytical technology (PAT) tool for monitoring the metabolism of host cells used in the biopharmaceutical industry. However, limitations of the method restrict its biological application.

Download this poster to explore the work of Rish et al., aiming to develop a calibration-free approach for intracellular quantification of a relevant biomarker to support PAT application of NMR spectroscopy.

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Review of nanoparticle-based strategies to combat COVID-19

Using a database search approach, this review explores the potential of nanotechnology-based tools for COVID-19 disease management. Download this poster to discover the nanoparticle (NP)-based strategies that can be used to combat COVID-19 and/or similar pandemics in the future; identified using combined principles from previous antiviral studies, and recent research conducted on SARS-CoV-2.

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Assessing contractility of 3D iPSC-derived muscle models for safety and discovery at high-throughput using a novel, label-free magnetic detection method

3D engineered muscle tissues (EMTs) are a promising tool to study cardiac contractile deficiencies in vitro. However, EMTs pose challenges as they can be complex to fabricate and require laborious optical imaging and image processing to measure contractility.

Download this poster to explore a study with a goal to design, build, and validate an EMT platform that uses 1) facile and scalable bioengineering approaches to generate tissues from a variety of cell sources, and 2) a label-free measurement technique capable of direct contractility assessment across several tissues in parallel.

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Engineered E. coli with an oxidative cytoplasm and efficient cleavage of N-terminal methionine

Lees et al., have developed a novel E. coli expression system, named Gor/Met E. coli, with an oxidative intracellular environment that can express disulfide-bonded proteins as soluble, properly folded intracellular proteins. Download this poster for insight into the potential of the Gor/Met E. coli as a commercially viable production strain for producing high yields of disulfide-bonded proteins with their native sequence.

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In vitro study of pulsed electromagnetic targeting of magnetic nanoparticles as potential anti-tumor therapy

In breast cancer, new treatment methods using electromagnetic fields (EMFs) could inhibit cell growth and proliferation, induce apoptosis, and suppress angiogenesis and metastasis.

Download this poster to discover the findings of this study in fluorescently determining the cellular effects caused by pulsed EMF and iron magnetic nanoparticles (MNPs) on cancerous MDA-MB-231 and healthy MCF-10A cells.

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Want to see more from our Virtual Biopharma Summit 2021? Click here to discover research from our brilliant lineup of guest speakers, the latest news in biopharma, and more!