Wide Range of Epigenetic Assay Kits for Genomic Research
24 Aug 2016Chromatrap is a pioneer in the development of solid-state filter-based technology that significantly enhances and accelerates the important epigenetic research tool of chromatin immunoprecipitation (ChIP).
The company has developed a range of optimized ChIP assay kits for use in many areas of genome research including classical qPCR, DNA sequencing and from formaldehyde fixed paraffin embedded samples (FFPE) using either discrete spin columns or dedicated 96-well filter plates.
The simplicity and efficacy of Chromatrap ChIP assays, enabling more IPs from less material, more quickly than traditional methods, has made them popular with a growing number of leading genetics research laboratories worldwide.
The Chromatrap 24 column ChIP-qPCR kit is a firm favorite with researchers worldwide offering a choice of sonication or enzymatic DNA shearing and is available with Protein A or G coupled filters for optimal DNA pull-down.
For peace of mind and confidence in method validation, a new premium version of the kit is now available that includes positive and negative control antibodies. This is especially useful where the target antibody has not been validated in ChIP before, as this can often give unexpected results which are hard to interpret without the use of controls.
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Chromatrap® FFPE ChIP Kit
ChromatrapEpigenetic identification and targeting in clinical FFPE tissues is a crucial step for potential epigenetic therapeutics and personalized medicine therapies. FFPE is a standard method to archive and preserve medical tissue biopsy samples. These archives, kept in many hospitals world-wide, are a huge, rich and untapped sample resource for genetic research. Due to the cross-linking of proteins by formaldehyde, FFPE tissues present a particular challenge for ChIP analysis. In addition, the small size and delicate nature of the tissue, and the difficulty in extracting samples from paraffin, used to provide tissue support after preservation, can damage complex cellular complexes such as chromatin. ChIP assays from these samples have therefore proved time consuming and difficult. Chromatrap® FFPE ChIP kit overcomes these issues and provides the following benefits: Provides greater flexibility and more IPs per sample Works across a range of FFPE samples, human and animal Available in 96-well plate or spin column format Works equally well with high and low abundant marks Provides sufficient DNA to perform library preps for ChIP-seq assays