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Thermo Fisher Scientific Offers Reagents for the Study of Synaptogenesis

20 Apr 2009
Veronica Austin
Marketing / Sales

Product news

Announcing the availability of the Thermo Scientific Cellomics Synaptogenesis High Content Screening (HCS) Assay Reagent Kit. This new Cellomics® HCS Assay enables the simultaneous fluorescence detection of neuronal population, neurite, pre-synaptic vesicle, post-synaptic punta and synapse. The individual targets, including a nuclear Rockford, Ill. (April 16, 2009) - Thermo Fisher Scientific, the world leader in serving science, marker, are detected using four fluorescent dyes. The assay can be used to study neuro-developmental pathways, neurological diseases and the neurotoxicity of compounds.

The Synaptogenesis HCS Assay Reagent Kit can be part of a total automated solution for HCS that includes Thermo Scientific Cellomics ArrayScan HCS Reader and the Neuronal Profiling BioApplication Software. The fluorescent images generated by the assay can also be viewed and analyzed by other fluorescence microscopes. The kit comes in two sizes, supplying sufficient reagents for 5 x 96 wells or 50 x 96 wells.

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AntibodiesAntibodies are used in techniques such as confocal and fluorescence microscopy, flow cytometry, ELISA, ELISPOT, immunohistochemistry, western blotting and immunopreciptation. Select specific antigen reactivity, high specific affinity, low non-specific binding, monoclonal or polyclonal, primary or secondary antibodies and associated conjugates such as an enzyme or dye for visualization.High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.ADME-ToxicologyADME-toxicology (ADME-Tox) studies are used in pharmacology and pharmacokinetics to assess the activity/toxicity of drugs <i>in vivo</i> or <i>in vitro</i>. Find bioassays for absorption, distribution, metabolism, and excretion of drug molecules including cytotoxicity, transporter/permeability, metabolism and activity assays as well as hepatocytes and cell lines for ADME. Find the best ADME-toxicology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.High-Content ScreeningHigh-content screening (HCS), also known as high-content analysis (HCA), is a high-throughput technique used in drug discovery to identify substances that alter the phenotype of cells. HCS uses fluorescent microscopic imaging and automated image analysis to investigate cellular events such as apoptosis, cell viability, GPCR activation, oxide production, neurite outgrowth, and cell signaling. Find the best fluorescent labeling reagents, cellular assays, and high-content imaging systems in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Automation Supplies / AccessoriesAutomated accessories and consumables make lab processes fast, efficient and reliable. Useful automation accessories include microplate sealers, label printers and reagent reservoirs.

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Thermo Fisher Scientific Offers Reagents for the Study of Synaptogenesis