SCIEX Launches SWATH Data Independent Acquisition Technology for Comprehensive Analysis of Food, Forensic and Environmental Samples

SCIEX, a global leader in life science analytical technologies, today announced that it has launched its game-changing SWATH^® data independent acquisition (DIA) technology for analytical scientists working across all application areas.

SWATH Acquisition is ground-breaking in allowing the simultaneous and comprehensive identification and quantification of virtually every detectable compound in a sample, from a single analysis (MS/MSALL). SWATH Acquisition has unique capabilities for quantitative accuracy, offering exceptionally high reproducibility across multiple samples with wide dynamic range. Importantly, the technology enables the creation of a permanent digital record of quantitative MS/MS data for the entire sample. Following the successful implementation of SWATH for proteomics research, this technology is widely used today in the industrialization of proteomics research and can now bring significant advantages for analytical scientists in other fields, including forensics, food testing, environmental analysis, and biologics.

The transition from traditional proteomics workflows to the SCIEX patented SWATH^® Acquisition has transformed proteomics experiments, allowing all data to be robustly captured across very large sample cohorts to enable industrialized proteomics and precision medicine approaches. The ability of the SCIEX TripleTOF^® system technology to acquire high resolution MS/MS spectra at high acquisition rates has made it the only mass spectrometer on which SWATH Acquisition can be routinely performed. Now with the new X500 series mass spectrometers, with the similar acquisition rates, on a routine use system SWATH Acquisition is now poised to revolutionize other fields.

“The most important aspect of the X500R QTOF System is the ability to work with SWATH Acquisition, especially when analyzing food samples with complex matrices,” said Dr. Amadeo R Fernaìndez-Alba, Head of the European Union Reference Laboratory (EURL) for Fruits and Vegetables, and Professor of Analytical Chemistry at the University of Almeria. “It also enables fast quantification, making it ideally suited to high-throughput applications, without compromising on sensitivity.”

“As environmental chemists, we are always trying to find new compounds of concern, whether in drinking water, stormwater, or biota,” said Christopher Higgins, Ph.D., Associate Professor, Department of Civil and Environmental Engineering, Colorado School of Mines. “SWATH looks to provide us an opportunity to collect and archive data, thereby allowing us to re-examine old data without reacquisition. This is an important advantage in environmental monitoring where samples are often limited.”

“The beauty of SWATH is that it collects data for everything,” said Dr. Thomas Kofoed, Chief Executive Officer, Alphalyse. “It allows us to identify and quantify each host cell protein reliably in drug batches, and provide a service that customers can trust.”

“SWATH is our preferred method for broad-based drug screening when using SCIEX QTOF systems, because SWATH enables the generation of accurate library MS/MS spectral matching results reducing the possibility of false negative identifications,” said Dr. Barry Logan, Executive Director, The Center for Forensic Science Research Education. “Essentially, SWATH provides reliable results for analytes that are toxicologically relevant to forensic investigations because of the complete MS/MS coverage that it provides.”

SCIEX will highlight the latest additions to its growing line of mass spectrometry-based solutions at ASMS 2017, June 4-8 in Indianapolis. SCIEX will present customer driven innovations and advancements for all markets, at booth #500 and in their hospitality suite at the JW Marriott – White River Ballroom ABE.