Pipettes take small molecule inhibitors from discovery to clinical trials

INTEGRA Biosciences supplies RAPT Therapeutics in San Francisco, USA, with pipettes to accelerate the development of its candidate small molecule inhibitors for the treatment of inflammatory diseases and cancers

25 Oct 2024

INTEGRA'S liquid handling solutions have helped RAPT Therapeutics' R&D team to efficiently analyze its lead drug candidates at every stage of the process – from discovery to clinical trials – driving its innovative therapies towards commercialization.

Courtesy of RAPT Therapeutics.

RAPT Therapeutics is a clinical stage, immunology-based biopharmaceutical company focused on small molecule therapies for various cancers and inflammatory diseases. It currently has two promising candidates in clinical trials. The company’s immunology laboratory uses INTEGRA pipettes to help develop and perform assays to characterize immune cell subsets after disease onset and drug administration, answering important questions that may arise before or after clinical trials.

Steven Lomeli Gonzalez, research associate in RAPT Therapeutics' Immunology Department, explains, “I work with EVOLVE manual pipettes and VIAFLO 96 electronic pipettes on a day-to-day basis, and find their performance outstanding. The VIAFLO 96 pipettes have been particularly useful for improving our productivity – which is critical for moving onto the next stage of a project – as we can dispense entire 96 well plates in one go.”

He continues, “With our efficient, ergonomic and accurate pipettes, we can continue to progress our small molecule inhibitors through clinical trials to improve cancer and autoimmune disease treatment. We all know someone that has been impacted by these disease areas, and we hope that getting our candidates to market quicker can help to improve the prognosis for patients in the future.”

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EVOLVE Manual Pipettes

INTEGRA Biosciences

Set volumes fast! The EVOLVE manual pipette features three adjustable dials to rapidly set volumes. This revolutionary approach reduces repetitive stress injuries and allows users to set volumes in a fraction of the time it takes with a traditional manual pipette. GripTip pipette tips that will never fall off EVOLVE pipettes together with INTEGRA’s wide range of GripTips form a perfect pipetting system. GripTips snap into place with minimal tip loading effort, providing a secure connection. GripTips never fall off and are perfectly aligned, ensuring precise touch offs of fluids resulting in superior pipetting performance. Operational comfort Two differently sized plunger springs allow users to customize the force needed to depress the plunger to their preference. The controlled plunger spring option allows users to slow the aspiration and dispense speeds resulting in improved pipetting technique and results. The controlled plunger spring is compatible with all single channel EVOLVE pipettes except the 5 ml model. Changing the spring is completed in seconds. The ultra lightweight, well balanced design of the pipettes provides unsurpassed ergonomics even during prolonged pipetting sessions. EVOLVE pipettes are available as single, 8,12 and 16 channel models. Features: Quick Set Dials Unlike traditional pipettes which utilize a single rotating plunger to set volumes, EVOLVE features one dial for setting each of three volume digits. This is the same convenient method used to unlock three dial combination locks. This revolutionary approach allows users to set volumes more than ten times faster than standard manual pipettes. Simply depress and twist the plunger to unlock the quick set volume dials. Once unlocked, freely adjust the three dials to rapidly set the desired volume. Volumes set on traditional manual pipettes can often change while pipetting due to unintentional plunger turns. The EVOLVE Quick Set Dial design prevents inadvertent volume drift due to plunger movements while pipetting. GripTip System Do your pipette tips ever loosen, leak or fall off? This is a common issue in laboratories, caused by the use of universal pipette tips. Such tips require “hammering on” which stretches the shape of the pipette tip rim. The stretched pipette tip rim immediately starts moving back to its original shape, away from the tip cone. This can cause leaking, misaligned tips and even pipette tips that completely fall off the pipette! This will never happen with any EVOLVE pipette / GripTip combination. Featuring a low attachment force and a low ejection force, GripTips effortlessly snap onto the tip fittings and are easily ejected. Also, GripTips feature a high lateral resistance once attached to the EVOLVE pipettes. This means GripTips are always firmly attached and perfectly aligned, regardless of how many side well touch offs are performed. You no longer have to hammer your pipette tips on or worry about pipette tips falling off! Interchangeable Plunger Spring Assemblies Two differently sized plunger springs allow users to customize the force needed to depress the plunger to their preference. The controlled plunger spring option allows users to slow the aspiration and dispense speeds resulting in improved pipetting technique and results. The controlled plunger spring is compatible with all single channel EVOLVE pipettes except the 5 ml model. Changing the spring is completed in seconds. INTEGRA Linear Stand Storing pipettes upright is important to prevent liquid or debris from entering the tip fitting. Proper storage also extends the life of a pipette. The INTEGRA linear stand is ideal for hanging EVOLVE pipettes up off the lab bench. Up to twelve manual pipettes can be placed on a linear stand. EVOLVE shelf hooks are also available for proper storage.

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