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Novus Biologicals Enhances Stem Cell Product Offering

Novus Biologicals, LLC
22 Jan 2010
Sarah Sarah
Marketing / Sales

Product news

Novus Biologicals has recently taken steps to broaden and enhance their product offering to stem cell researchers. Novus recently constructed a new laboratory facility specifically designed for testing stem cell products at their headquarters in Littleton, Colorado. This tissue culture lab will allow Novus to validate their antibodies for use in Immunocytochemistry, Immunofluorescence and Flow Cytometry.

Antibodies specific for stem cell markers will be validated using the human embryonal carcinoma cell line NTERA-2 as well as standard laboratory cell lines including HeLa, Jurkat, NIH/3T3 and RAW 264.7. In addition, six stem cell marker antibodies were recently validated for flow cytometric analysis (FACS), including:

• Nanog Antibody (NB100-588)
• OCT4 Antibody (NB100-2379)
• TRA-1-60 Antibody (NB100-730)
• TRA-1-81 Antibody (NB100-1833)
• SSEA1 Antibody (NB100-1831)
• SSEA3 Antibody (NB100-1832)

Novus has also expanded their stem cell product line by launching two new products. Novus' DGCR8 knockout mouse embryonic stem cells (catalog #: NBA1-19349) are unique because they allow for the specific study of the global role of microRNAs. Unlike the Dicer cell line, the only other comparable line for studying microRNAs, the DGCR8 cell line appears to be specific for microRNAs, whereas Dicer also affects other classes of small RNAs. Novus also recently launched a new rabbit polyclonal anti-Borealin antibody (catalog #: NBP1-22832). Borealin, or CDCA8, is a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis, and has been shown that it is differentially expressed in embryonic stem cells and is essential for the early development. This new Borealin antibody has been tested in Western blot on mouse kidney lysate where a band at ~38kDa was visualized, and is also useful for human and rat tissues.

Novus' Stem Cell Antibody Catalog, released in September 2009, contains background information on embryonic stem cells, adult stem cells, tissue/organ specific stem cells, cancer stem cells, in addition to their stem cell product line. Similar information can also be found on Stem Cell Markers webpage. Novus’ Stem Cell eNewsletter is a free publication that features the latest news and discoveries in stem cell research, stem cell technique discussion, stem cell meeting calendar, as well as new stem cell product highlights.

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Fluorescence SpectroscopyFluorometers and spectrofluorometers (also called fluorescence spectrometers) are used to measure the intensity and wavelength of fluorescent light emitted from a sample after excitation by illumination. Spectrofluorometers utilize monochromators to select the desired wavelengths, whereas filter fluorometers employ a set of filters. Spectrofluorometers for measuring steady-state fluorescence and lifetime fluorescence (or time-resolved fluorescence) are available, as well as fluorescence microscopes and microplate readers. Find the best fluorescence spectroscopy products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.AntibodiesAntibodies are used in techniques such as confocal and fluorescence microscopy, flow cytometry, ELISA, ELISPOT, immunohistochemistry, western blotting and immunopreciptation. Select specific antigen reactivity, high specific affinity, low non-specific binding, monoclonal or polyclonal, primary or secondary antibodies and associated conjugates such as an enzyme or dye for visualization.Cell Lines Stem Cells and Primary CellsPrimary cell cultures, established cell lines and stem cells are vital for <i>in vitro</i> and <i>ex vivo</i> experimentation. High-quality cells, optimized for your applications, alongside optimized cell substrates, growth medium and supplements, are critical for experimental success. Explore a range of cells suitable for your applications, including isogenic cell lines, competent cells, induced pluripotent stem cell (iPSC)-derived cell lines, fungal/bacterial/mammalian cell lines, stem cells and cancer cell lines. Find the best cells for your research in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Flow Cytometry / Cell CountingFlow cytometers are used to count, sort and examine multiple characteristics of cells. Other cell analysis equipment includes image cytometers, cell counters, fluorescence-activated cell sorters (FACS), magnetic-activated cell sorters (MACS), and a range of flow cytometry assay kits. Flow cytometers can reveal information on cell viability, cell proliferation, apoptosis and cell cycle progression, as well as identify cell populations and intracellular or cell-surface molecules. Additionally, some flow cytometers, known as FACS, have an additional sorting function after analysis. Cell counters and image cytometers count live and dead cell populations and can also conduct cell proliferation assays. Find the best flow cytometers, cell counters and cell sorters in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.

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Novus Biologicals Enhances Stem Cell Product Offering