New Chemiluminescent Application of G:BOX Image Analyzers Makes Accurate Imaging of Microarrays Accessible to all Laboratories

30 Sept 2007

Product news

Syngene, a world-leading manufacturer of image analysis solutions, is pleased to announce two of its G:BOX multi-application imaging systems have shown excellent performance with SuperArray Bioscience’s Oligo GEArrays®, offering researchers a precise method of characterizing gene expression.

Researchers at the leading array manufacturer, SuperArray Bioscience, have evaluated their Oligo GEArrays using the G:BOX Chemi HR16 and G:BOX Chemi XT16 imaging systems. They found using a G:BOX Chemi HR16, they could image eight arrays simultaneously and with the G:BOX Chemi XT16, 32 arrays at the same time. They also showed both systems had excellent dynamic range and their cooled cameras allowed the long exposure times of 20 minutes often required to get maximum signal, with low background noise on the resulting images.

Dr Ray Blanchard, Senior Scientist, at SuperArray Bioscience explained: "Many researchers use X-ray film, followed by scanning and densitometry to analyze chemiluminescent microarrays, but by doing this, they can lose around 80 percent of the information just in the handling. Using the right CCD based system scientists can capture much more data, producing quantitative analysis and, as a result, reliable gene expression measurements.”

Dr Blanchard continued: “Not all CCD based analyzers can image arrays, and we have a check list of criteria these systems must meet before they are recommended for imaging Oligo GEArrays. Both the G:BOX Chemi XT16 and G:BOX Chemi HR16 successfully meet all our requirements, not only on paper, but also during our tests to generate high quality images of Oligo GEArrays.”

Paula Maia, Vice President of Sales, Syngene US concluded: "We are delighted to see our systems performing well in this important application because it shows that any laboratory can confidently harness the powerful combination of Oligo GEArrays and G:BOX systems to deliver accurate gene expression results every time.”

G:BOX F3

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An entry level system for imaging fluorescence and visible applications, the G:BOX F3 gel doc is the ideal solution for your laboratory.

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Genome AnalysisGenomics, the study of genomes, includes functional genomics, evolutionary genomics and comparative genomics. There are many genomic technologies such as DNA sequencing of whole genomes, computational biology and bioinformatics. DNA and nucleic acids must be isolated and concentrated from cells for analysis with kits, automated analyzers and software. Other useful technologies for studying genomics include PCR, microarrays and electrophoresis.OligonucleotidesOligonucleotides are small nucleic acid polymers, usually less than 20 bases in length. Oligonucleotides can be made via enzymatic cleavage or more commonly by chemical synthesis with polymerases. Their use includes FISH, southern blots, microarrays and as primers in PCR. High fidelity synthesis kits and detection systems are available for easy production and detection, respectively.Gel Doc / Image AnalysisGel documentation (gel doc) or gel imaging systems are used for the analysis of proteins, antibodies and nucleic acid immobilized in polyacrylamide or agarose gels, membranes or microarrays. Explore a range of a gel imaging systems, densitometers, scanners, transilluminators or UV lamp + CCD cameras for your image analysis solutions. Colorimetric, fluorescent and/or radioisotopic samples can be visualized and documented for further analysis. See gel doc / Image analysis software for quantitative 1D and 2D analysis of your samples. Find the best gel doc / image analysis products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Microarray AnalysisMicroarrays, also known as biochips, are used for the detection and analysis of multiple genes, proteins, antibodies, or biomarkers on a single microchip. This can reveal information on protein or gene expression, single nucleotide polymorphism (SNP), copy number variation (CNV), epigenetics and patient health in clinical diagnostic tests. Discover a range of microarray scanners and prefabricated antibody, protein, RNA and DNA microarrays for your analysis or consider creating your own custom microarrays with a microarray printer. Find the best microarray products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.
New Chemiluminescent Application of G:BOX Image Analyzers Makes Accurate Imaging of Microarrays Accessible to all Laboratories