Large scale magnetic separation for the purification of mAbs directly from cell culture
12 Sept 2025Chromatography remains central to downstream bioprocessing, especially in monoclonal antibody (mAb) production, where clarified cell cultures are essential to prevent interference with packed beds. As upstream intensification drives higher cell densities, traditional clarification methods such as centrifugation and filtration have become costly bottlenecks, adding complexity without directly contributing to product purity or concentration.
Discover how scalable magnetic separation technology offers a transformative alternative. By combining clarification and capture into a single step, it streamlines workflows, conserves resources, and boosts yield to empower researchers to rethink efficiency in advanced biomanufacturing.
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MAGic™Accio System Process
MAGic BioProcessingMAGic™Accio PROCESS are our large fully automated magnetic separator systems, made for efficient capture of 1-40 liters of MAGic™Beads magnetic beads from large volumes of complex feedstocks. During the production phase of biopharmaceuticals, large-scale recovery of the product from an unclarified cell-culture is performed in a one-step clarification and purification by using the proprietary designed MAGic™Accio PROCESS units together with our MAGic™Beads. The magnetic separators are capable to capture up to 40 liters of MAGic™Beads at high flow rates making them suitable to process up to kilograms of proteins or antibodies per purification cycle and fully integrated in existing manufacturing workflows.
MAGic™ Beads Protein A
MAGic BioProcessingMAGic™ Beads Protein A offer one-step clarification and capture of monoclonal antibodies, eliminating the need for centrifugation, depth filtration and Protein A affinity column-chromatography. Super-paramagnetic porous beads coupled with an alkali resistant Protein A ligand.