Large liquid volume evaporation to benefit Medicinal Chemistry
21 Feb 2006Genevac Ltd, leader in solvent evaporation technology, has announced further additions to its range of large volume sample holders for its EZ-2 and HT series centrifugal evaporators.
With medicinal chemistry departments needing to scale up syntheses to meet the increasing demand of ADME, Toxicology and Safety Testing - the need for safe and efficient removal of larger volumes of solvent has been increasing.
Ingenious sample holder design has allowed the compact, benchtop EZ-2 to accommodate up to six 100ml flasks simultaneously. With larger round-bottomed flasks, a total capacity of 1 litre is possible, for example 4 x 250ml or 2 x 500ml. On the larger capacity HT-4X system - new holders have been introduced that enable simultaneous evaporation from 4 x 500 ml Nalge bottles or 4 x 250 ml Schott media bottles.
The new sample holders allow users to evaporate large volumes, as they would on a rotary evaporator, in a single productive run but with the added sample temperature and bumping protection safety features afforded by the EZ-2 and HT-series evaporators.
Many years of experience in solvent evaporation and sample purification have allowed Genevac to produce high-efficiency sample concentrators that deliver high performance, ease of use, high reliability, and compatibility with most commonly used solvents and acids.
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EZ-2 Series
GenevacUsing the most advanced proven technology in evaporation science, the third generation of the EZ-2 Series has been designed specifically for solvent removal in life science research; be that concentration of samples or complete drying. The innovative design of the EZ-2 Series presents many advantages for working in parallel within synthesis chemistry, analytical sample preparation and for general-purpose solvent removal needs in life science laboratories. At the heart of the evaporator is a solvent resistant, oil-free vacuum pump, and the high efficiency, defrost-free, SpeedTrap™, which traps all solvents as liquids, even water. Solvents collect in the insulated, plastic coated glass vessel, enabling the user to see the progress of evaporation and determine when the trap should be emptied. The EZ-2 Elite has a special auto-draining collection vessel fitted to the SpeedTrap, which uses the very powerful Scroll pump. The Elite can therefore evaporate the highest boiling solvents such as DMSO and perform the Genevac LyoSpeed fast lyophilisation method for HPLC fractions. There is a low-cost option available on the Standard, Plus and Elite that allows the routine use of hydrochloric acid and aggressive solvents. By building key elements in Hastelloy®, glass or PTFE, full protection against acid chlorides is achieved. New to the HCl Resistance option is the ability to evaporate concentrated nitric acid. This option must be specified when ordering, as it cannot be retrofitted. All EZ-2 models are resistant to routine use of high concentrations of TFA as standard. An additional option is available to allow safe operation for those wishing to use highly explosive solvents, such as pentane or diethyl ether - the inert gas purge system. This system can also be used to preserve oxygen or moisture sensitive samples under an inert gas blanket until the user returns to the evaporator. The EZ-2 Series can also accommodate a wide selection of sample holders, including round-bottom flasks up to 500ml, tubes up to 160mm long (including Dionex ASE® and Radleys Carousel tubes), custom reaction blocks, and shallow or deep-well microtitre plates. EZ-2 Series Models: The Standard (EZ-2) is suitable for water and volatile solvents The Envi (EZ-2 Envi) is recommended for concentration of volatile solvents The Plus (EZ-2 Plus) is recommended for solvents with boiling points upto 165°C The Elite (EZ-2 Elite) is recommended for solvents with boiling points upto 220°C