Improved Clinical Flow Cytometry Accuracy with ClearLLab LS Lymphoid Screen Reagent

1 Nov 2016
Emily Adam
Publishing / Media

Product news

Beckman Coulter Life Sciences further has demonstrated its expertise in clinical flow cytometry with the launch of ClearLLab LS Lymphoid Screen Reagent, Europe’s first CE-marked 10-colour, 12 antibody reagent combination for leukemia and lymphoma analysis.

The ClearLLab LS Lymphoid Screen delivers greater confidence in results with a faster turnaround time (TAT). It eliminates 14 manual workflow steps, while streamlining five others; and is available through a dry unitized, ready to use formulation. ClearLLab has been specifically designed for the fast and accurate identification of hematolymphoid cell populations on the company’s Navios flow cytometer.

Mario Koksch, vice president and general manager of Beckman Coulter’s Cytometry Business Unit said: “Beckman Coulter provides lab scientists with the tools they need to standardize and streamline workflow when using high content flow cytometry in clinical decision-making. By eliminating 14 workflow steps, we empower them to achieve much faster and more consistent turnaround times.”

Flow cytometry offers significant advantages over other cell-based techniques, such as precision, speed, the preservation of cell viability and cellular functions, and simultaneous measurements of multiple cellular parameters. As Dr Kosch explained: “If survival rates are to be improved, we need to be able to diagnose life-threatening hematolymphoid diseases as quickly as possible. With ClearLLab LS Lymphoid Screen, the lab now has the means to speed up the delivery of patient results to clinicians, while having added confidence in their accuracy.”

The ClearLLab LS Lymphoid Screen is the first of an advanced range of Beckman Coulter clinical flow cytometry products which will cater to different global workflow requirements over the next five years. It is compatible with the World Health Organization (WHO) 2008-revised classification of myeloid neoplasms and acute leukemia. WHO, in collaboration with the European Association for Hematopathology and the Society for Hematopathology, made important changes to the classification of these diseases, including new criteria for the recognition of some previously described neoplasms as well as clarification and refinement of the defining criteria for others.

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Flow Cytometry / Cell CountingFlow cytometers are used to count, sort and examine multiple characteristics of cells. Other cell analysis equipment includes image cytometers, cell counters, fluorescence-activated cell sorters (FACS), magnetic-activated cell sorters (MACS), and a range of flow cytometry assay kits. Flow cytometers can reveal information on cell viability, cell proliferation, apoptosis and cell cycle progression, as well as identify cell populations and intracellular or cell-surface molecules. Additionally, some flow cytometers, known as FACS, have an additional sorting function after analysis. Cell counters and image cytometers count live and dead cell populations and can also conduct cell proliferation assays. Find the best flow cytometers, cell counters and cell sorters in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.HematologyIn Haematology / Hematology, complete blood cell counts (or full blood counts) are obtained using automated blood count analyzers to enumerate blood cell types.  Hematology also encompasses haemostasis and coagulation, thrombophilia and hemophilia, plasma viscosity and ESR analysis, hemoglobinopathies, cell morphology and haematinic measurement.Cellular PathologyCellular Pathology deals with the microscopic analysis of tissue samples and cells. Sample preparation and processing includes fixation, staining, sectioning and slide mounting, using equipment such microtomes and cryostats. In choosing immunohistochemistry and immunocytochemistry kits, consider chromogens, staining method, antibodies, microscopes and imaging.Hematology SolutionsHematology solutions involve diagnostic tests and equipment used to analyze blood samples and diagnose blood disorders such as anemia, leukemia, and hemophilia. These tools include automated full blood count analyzers, reagents, and digital morphology systems. Explore hematology solutions in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.Cell BiologyCell biology studies the structure, function, and behavior of cells. Understanding cellular processes is essential for research in areas such as cancer biology, stem cell research, and neurobiology. Techniques like flow cytometry, microscopy, and cell culture enable researchers to explore cellular mechanisms in detail. Browse our peer-reviewed product directory to find the best cell biology tools and equipment, compare products, check customer reviews, and get pricing directly from manufacturers.Clinical StudyProspective biomedical or behavioral research studies on human subjects, following tests in animals, that are designed to answer specific questions about novel vaccines, drugs, treatments, dietary supplements, devices or new ways of using known interventions, generating safety and efficacy data.Biomarker DiscoveryClinical biomarkers refer to substances related to known medical conditions that can be accurately measured <i>in vitro</i>. Biomarkers can be used to diagnose presence of a disease and indicate disease severity. The discovery of new biomarkers is incredibly valuable in the field of diagnostics.