Impressive performance per dollar with CLC Bioinformatics Cell 2.0 from CLC bio

22 Aug 2007
Greg Smith
Analyst / Analytical Chemist

Product news

With the release of CLC Bioinformatics Cell 2.0, the world's leading bioinformatics solution provider, CLC bio, raises the bar significantly in terms of performance per dollar in high-performance bioinformatics. Through SIMD technology the Bioinformatics Cell enables users to parallelize calculations on their existing Intel- or AMD-based computers, servers, and clusters - and thereby increase the performance dramatically.

CLC bio's Chief Scientific Officer, Bjarne Knudsen, states, "CLC Bioinformatics Cell accelerates well-known algorithms, such as Smith-Waterman up to 144 times, ClustalW up to 30 times - and in this new version also Sean Eddy's HMMER algorithm up to 37 times. These accelerations are on existing hardware, so scientists don't not need to buy new hardware to get these accelerated algorithms. The speed-up factor varies depending on the processor used, but new multi-core CPUs delivers the best overall performance. However, users will also experience remarkable speed-up factors on hardware that is more than two or three years old, so implementing the Bioinformatics Cell can also be used to effectively prolong a hardware life cycle."

Eliminating the need to purchase additional hardware when opting for a solution including the Bioinformatics Cell, gives users a much more flexible and cost-effective approach to high-performance computing. This means that IT administrators in data centers can prolong the life cycle of their clusters and servers, instead of continually having to stretch the budget to purchase new hardware.

As an example, a 3.0 GHz Pentium 4 can run Smith-Waterman at 0.05 GCUPS (Giga Cell Updates Per Second) with no acceleration, and 3.0 GCUPS with the Bioinformatics Cell implemented. A new 8-core Intel processor can run the same algorithm at 0.31 GCUPS without CLC Bioinformatics Cell - and 44.50 GCUPS with it. A massive 144 times speed-up on the same processor. For a complete benchmark test on four different computer processors, a thorough white paper on the Bioinformatics Cell can be downloaded from the article webpage.

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Genome AnalysisGenomics, the study of genomes, includes functional genomics, evolutionary genomics and comparative genomics. There are many genomic technologies such as DNA sequencing of whole genomes, computational biology and bioinformatics. DNA and nucleic acids must be isolated and concentrated from cells for analysis with kits, automated analyzers and software. Other useful technologies for studying genomics include PCR, microarrays and electrophoresis.ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.Chem / BioinformaticsCheminformatics and bioinformatics are computational techniques used in chemistry and biology, respectively, for data acquisition, processing and storage. Cheminformatics focuses on compound information, whereas bioinformatics is mainly applied to analysis and modeling of genomics, genetic and sequencing information. Hardware and software is available for data acquisition, analysis, management and storage.DNA SequencingDNA sequencing, such as sanger sequencing, is a biological technique that determines the precise order of nucleotide bases in a fragment or template of DNA. DNA sequencers and genetic analyzers are based on capillary electrophoresis, where labeled DNA fragments are electrophoretically separated by size as they migrate through a polymer. Find the best DNA sequencing products, including DNA sequencing kits, genomic libraries and genetic identity kits in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.