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Human primary cell culture tools for COVID-19 research from PromoCell

PromoCell GmbH

The company is providing well-characterized and standardized human primary cells with matching specialty cell culture media

17 Jun 2020
Diane Li
Assistant Editor

Industry news

As the global COVID-19 pandemic evolves, researchers worldwide are working hard to study the mechanisms underlying SARS-CoV-2 infection. Thanks to their discoveries, new insights for developing treatments, vaccines and diagnostic tools are being made possible. As a leading manufacturer of human primary cells and cell culture products, PromoCell is lending its expertise to support the efforts of researchers worldwide to study, understand and combat this new health threat.

During virus infection, the respiratory tract epithelium forms a physical barrier that pathogens encounter. Understanding this barrier is greatly enhanced by having well characterized and standardized cell culture models of the epithelium. The ability to model the different properties and functions of the respiratory tract in vitro is key to successfully translating research findings into real-world medical applications.

Cell lines are often derived from tumor tissue and display modified gene and protein expression patterns. Therefore, cell lines are unable to give true insight into how SARS-CoV-2 interacts with human tissue. Using human primary airway epithelial cells for infection studies allows researchers to study how the SARS-CoV-2 virus interacts with a natural host. This contrasts with studying the virus in cell lines, which are often derived from tumor tissue and display modified gene and protein expression patterns. Cell lines are therefore unable to give a true insight into how SARS-CoV-2 interacts with human tissue.

Advantages of using Human Primary Cells

  • A wide range of available donors give you access to primary cells from different genetic backgrounds and health status parameters (e.g. donors with COPD or asthma)
  • Access to cells from various tissue localizations (nasal, tracheal, bronchial, small airways)
  • A large stock inventory so you can plan multiple experiments using the same donor and media reagents

PromoCell is underlining its role as a dedicated supporter of scientific research and innovation by providing well-characterized and standardized human primary cells with matching specialty cell culture media. Alongside their portfolio of cell culture tools, their team of scientists are ready to lend a hand with every research need or questions regarding SARS and ACE2.

Leading virology labs around the globe rely on PromoCell products to develop new strategies in the fight against COVID-19, with recent publications from Pöhlmann (Göttingen, DE), Drosten (Charité, DE), Eils (Berlin Inst. of Health, DE), and Ingber (Boston, USA) provide key insights into this work and PromoCell’s role.

PromoCell also offers a wide range of antibodies, blocking peptides, and cell-based / drug screening assays for SARS and ACE2 research.

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Cell / Tissue CultureCell culture or tissue culture is used to study the biology of cells or tissues and to isolate cellular products in an environment which can be manipulated and well defined. Accurately control your culture environment with bioreactors or culture incubators, bind your cells to a surface or together with an extracellular matrix. Distinguish cell types with differential media or proliferate cells with certain characteristics using selective media. Enrich your media with supplements such as growth factors, sera and vitamins. Find the best cell and tissue culture products, kits and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Combinatorial ChemistryCombinatorial chemistry, also known as combichem, is a technique used in drug discovery to create libraries of structurally related compounds. A library is generated by synthesis with a chemical reactor system or by computer-based modeling of compound combinations. When undertaking combinatorial chemistry consider reagents, buffers, resins and standards.Cell Lines Stem Cells and Primary CellsPrimary cell cultures, established cell lines and stem cells are vital for <i>in vitro</i> and <i>ex vivo</i> experimentation. High-quality cells, optimized for your applications, alongside optimized cell substrates, growth medium and supplements, are critical for experimental success. Explore a range of cells suitable for your applications, including isogenic cell lines, competent cells, induced pluripotent stem cell (iPSC)-derived cell lines, fungal/bacterial/mammalian cell lines, stem cells and cancer cell lines. Find the best cells for your research in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Data AnalysisData analysis hardware and software is available to make data processing straight-forward yet powerful. Data software can be used for math and stats, technical graphing and image analysis. In addition, software is available for specific data analysis of electrophoresis, densitometry, ELISA and DNA sequencing.ImmunologyImmunological techniques measure and characterize immune responses. Immunology kits and analysis systems often use techniques such as ELISA, radioimmunoassay (RIA) and immunodiffusion assays, Immunohistochemistry, and flow cytometry. Immunologists use equipment such as flow Cytometers, plate readers, plate washers and fluorescent microscopes.Cellular PathologyCellular Pathology deals with the microscopic analysis of tissue samples and cells. Sample preparation and processing includes fixation, staining, sectioning and slide mounting, using equipment such microtomes and cryostats. In choosing immunohistochemistry and immunocytochemistry kits, consider chromogens, staining method, antibodies, microscopes and imaging.Biopharmaceutical AdvancesBiopharmaceutical advances follow the development of pharmaceuticals derived from biotechnology, also known as biotechnology medicines. Biopharmaceuticals may be produced from cell lines, plants, or microbial cells. Important considerations of biopharmaceutical use include application, cost, production process and purification.Clinical ChemistryBiochemistry (or clinical chemistry) involves the analysis of bodily fluids using chemical tests. Techniques used include HPLC, chromatography, spectroscopy, mass spectrometry, immunochemical, electrophoresis, turbidometric / spectrophotometric assay, MRI and ISE analysis. Tests are often carried out on plasma or serum but urine (urinalysis) and fecal specimens are also processed.Clinical GeneticsMolecular Genetics covers the analysis of hereditary genetic disease and chromosomal abnormalities. Genetics can be analysed using DNA, RNA, and protein microarrays, PCR, RT PCR and DNA sequencing. Genetic equipment includes genetic workstations, thermal cyclers, cooling blocks and electrophoresis products. Diagnostic kits are used for DNA / RNA extraction and purification.Drug DeliveryDrug Delivery refers to dosage form, route of administration, formulations, technologies, and systems for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic effect. Drug delivery is often approached via the biopharmaceutical or small molecule drug's formulation, but it may also involve medical devices or drug-device combination products. Considerations include instrumentation, software and services. Respiratory InfectionsRespiratory infections are caused by pathogens such as bacteria, viruses, and fungi, leading to diseases like pneumonia, tuberculosis, and COVID-19. It is important to identify respiratory infections quickly in patients to ensure appropriate treatment and care, and to prevent sepsis. Browse our peer-reviewed product directory to find the best tools for respiratory infection detection, compare products, check reviews, and get pricing directly from manufacturers.VirusesViruses are microscopic pathogens that require a host cell to replicate. Understanding their structure, replication cycle, and impact on the immune system is crucial in developing effective treatments, vaccines, and diagnostic methods. Research continues to focus on emerging viral diseases and antiviral drug discovery. Explore solutions for virus research, detection, and treatment in our peer-reviewed product directory; compare products, check customer reviews, and get pricing directly from manufacturers.hiPS Cell LinesCoronavirusCoronaviruses are a large family of viruses that can cause illnesses ranging from the common cold to more severe diseases like COVID-19. Research into the biology, transmission, and treatment of coronaviruses has become a global priority, particularly since the emergence of SARS-CoV-2. Understanding the virus�s structure and behavior is essential for developing vaccines, diagnostics, and antiviral treatments. Explore our peer-reviewed product directory to discover the latest research tools, diagnostic tests, vaccines, and treatments for coronavirus, compare products, read reviews, and receive pricing directly from manufacturers.

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Human primary cell culture tools for COVID-19 research from PromoCell