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Fully-Validated SIRT1 Enhances Drug Discovery Investigation

6 Jul 2010
Sarah Sarah
Marketing / Sales

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BIOCIUS Life Sciences Inc. announces collaboration with BlueSky Biotech to offer the industry’s only Sirtuin (SIRT, silent mating type information regulation homolog) enzyme preparations fully-validated in a label-free functional assay. This collaboration builds on an existing partnership and will significantly improve drug discovery efficiency of the SIRT class of epigenetic modulating enzymes, which are being heavily investigated as promising therapeutics for several indications.

“Our latest endeavor with BIOCIUS provides researchers with a pre-validated assay solution that saves time and money, and further demonstrates the synergy of our high quality proteins combined with BIOCIUS’s value-added screening solutions ” said Paul Wengender, CEO, BlueSky Biotech, Inc. According to William LaMarr, Vice President of Research and Contract Services at BIOCIUS, “validation using a label-free, functional assay is especially important for sirtuins given the controversy surrounding fluorescent based assays recently seen in the scientific literature.”

The collaboration intends to launch a selectivity panel of sirtuins and histone deacetylases (HDACs). The activity of the first release, SIRT1, has been linked to the regulation of multiple cellular processes including insulin signaling, apoptosis, and cancer, making SIRT1 an important therapeutic target for a variety of conditions. The two companies plan to release additional validated enzymes over the course of the coming months. You can download the SIRT1 Application Note from the BIOCIUS website resources section.

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ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.Process ChemistryProcess chemistry is an important stage of drug development for scaling-up drug production or chemical synthesis reactions. It is useful for optimizing economical and efficient drug production. Process chemistry uses reactors and pump systems as well as reagents, standards and buffers.Protein PurificationProtein purification is a vital step in drug discovery, therapeutics, biotech and life science research. The purification process typically involves subcellular or membrane protein extraction with cell lysis kits, separation of proteins from cell debris by filtration or spin columns, and the isolation of proteins of interest from other proteins and impurities with affinity purification (including fusion protein tags and antibody binding proteins A, G and L), immunoprecipitation or chromatographic methods, such as ion exchange, size exclusion and immobilized metal affinity chromatography. All purification methods come in multiple formats for your laboratory needs, including agarose or magnetic beads, resins, columns and filter plates. Find the best protein purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.

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