CardiNor has secured NOK12 million (US$1.46M) to commercialize first secretoneurin ELISA test

The growing heart failure pandemic increases need for new innovative assays

28 Apr 2021
Ellen Simms
Product and Reviews Editor

Industry news

CardiNor AS has announced that it has secured NOK12 million (1.46M USD) to commercialize the development of an ELISA test for secretoneurin (SN), a potentially new innovative biomarker for cardiovascular disease. The Norwegian diagnostics company will use the funds for CE marking, initiate US regulatory activities and to expand the range of indications. In addition to existing investors, CardiNor also attracted health tech specialist Intuitive Investments Group plc.

CardiNor AS has announced that it has secured NOK12 million to commercialize the development of an ELISA test for secretoneurin (SN), a potentially new innovative biomarker for cardiovascular disease. The Norwegian diagnostics company will use the funds for CE marking, initiate US regulatory activities and to expand the range of indications. In addition to existing investors, CardiNor also attracted health tech specialist Intuitive Investments Group plc.

SN is the only cardiovascular biomarker shown to be associated with biological processes linked to cardiomyocyte Ca2+ handling. This unique biological function explains why SN presents as an independent and strong predictor of mortality in major patient cohorts, including ventricular arrhythmia, acute heart failure and acute respiratory failure patients with CVD and severe sepsis.

CardiNor has already been able to demonstrate SN’s potential clinical value in two specific areas – support patient selection for implantable cardioverter defibrillators and heart failure patient discharge eligibility. With access to several world-renowned clinical cohorts, further documentation of SN’s clinical value is under way.

“We are delighted to have closed this latest round and attracted international investors of the calibre of IIG,” commented Dag Christiansen, CEO, CardiNor. “The rise of heart failure worldwide is alarming and described as reaching pandemic levels. Our aim is to develop a routine test for this important marker which we believe will provide clinicians with a key tool for both more accurate risk prediction and patient management.”

“Secretoneurin has the potential to be a game changer in cardiovascular disease,” adds Robert Naylor, CEO of IIG. “We were impressed with the CardiNor team’s expertise and vision and look forward to supporting them as they bring the product though to market.”

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ELISAEnzyme-linked immunosorbent assays (ELISA), also known as enzyme immunoassays (EIA), are used for the detection and quantification of proteins, peptides and antibodies in a sample. ELISA often comes in kit format, with pre-selected antibody pairs to detect specific proteins or biomarkers of diseases such as diabetes and obesity, or cardiovascular and neurological disorders. Detection is made possible with chemiluminescent, fluorescent or colorimetric substrates and detection instruments such as microplate / ELISA readers. Other kits available include: Enzyme-linked immunospot (ELISPOT) assays for the quantification of protein-producing cells and chemiluminescent immunoassays (CLIA) kits. Find the best ELISA kits and products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :CardiologyBiomarker DiscoveryClinical biomarkers refer to substances related to known medical conditions that can be accurately measured <i>in vitro</i>. Biomarkers can be used to diagnose presence of a disease and indicate disease severity. The discovery of new biomarkers is incredibly valuable in the field of diagnostics.
CardiNor has secured NOK12 million (US$1.46M) to commercialize first secretoneurin ELISA test