Analytik Reports the Use of a Schmidt + Haensch Polarimeter for the Characterization of Chiral Molecules

Analytik, leading suppliers of innovative analytical instrumentation to the UK and Ireland, partner with German company, Schmidt + Haensch, for the supply of market leading polarimeters and refractometers, is pleased to report on the use of Schmidt + Haensch Polartronic H532 Polarimeter at the University of Leeds, School of Chemistry.

Professor Andrew J Wilson is Professor of Organic Chemistry in The School of Chemistry at the University of Leeds and current Deputy Director of the Astbury Centre for Structural Molecular Biology. His interests include the application of synthetic chemistry to problems in chemical biology and nanotechnology.

Research in the Organic Chemistry Section at Leeds is broad ranging covering drug discovery and chemical biology through to fine chemicals synthesis, the development of synthetic methods and materials synthesis. The research is motivated by modern day grand challenges such as the need for efficient and environmentally friendly synthetic methods and for new chemical entities to combat emerging therapeutic targets.

Polarimetry is regarded as a standard analytical characterization technique. The Leeds Schmidt + Haensch Polartronic H532 Polarimeter is primarily used for the characterization of chiral molecules that have been synthesized in the School of Chemistry, either for confirmation of specific rotation of a previously reported molecule, or for the completion of the characterization of a novel molecule to appropriate scientific rigor. For example, some researchers are involved in the synthesis of unnatural amino acids, where it is essential that enantiopurity is established before further experimentation is done - where specific rotations are cornerstone in confirming chiral purity of synthesized molecules.

The previous school polarimeter had been in use for many years. Its resolution had become inferior and the instrument had become unreliable in terms of measurement accuracy and reproducibility so the decision was made to replace it.

Speaking about the reasons behind choosing the Schmidt + Haensch polarimeter, Professor Wilson said “the benefit of the S&H polarimeter is the precision of the instrument which can resolve and stabilize rotations to four decimal places rapidly and consistently. The specific rotation calculation is also a useful feature that has been well used by members of the department. Researchers within the school who have been using the polarimeter are pleased with its performance and simplicity.”

Schmidt + Haensch have pioneered the technology behind polarimetry and refractometry. They now hold several key patents, enabling them to produce opto-electronic measuring instruments of the highest quality and accuracy. Their automatic digital polarimeters are designed to characterize optical active substances in the most demanding quality control and research laboratories.

Ian Laidlaw, Managing Director at Analytik comments: “The competition that can even approach the H532 with respect to accuracy can only achieve it within the range of ±1°. The H532 achieves the same level of accuracy across the full measurement range of ±89°. This is an exceptional instrument, recommended also by PerkinElmer Inc, a global technology leader in multi-vendor laboratory services, software and informatics.” '