50th Rigaku ACTOR™ robotic protein crystal handling system purchased by the Medical Research Council
7 May 2008Rigaku Americas Corporation is pleased to announce the sale of the 50th Rigaku ACTOR robotic protein crystal handling system to the Medical Research Council (MRC) Laboratory of Molecular Biology in Cambridge, UK.
The system was chosen by the MRC as an upgrade for their in-house X-ray diffraction facilities and in support of crystallographic studies carried out in the laboratory, which seek to understand the structure, function and interactions of biologically important molecules at the atomic, molecular and supra-molecular level. A significant milestone for Rigaku, sale of the 50th ACTOR will be marked by a special commemorative plaque affixed to the exterior of the instrument. Dr. Andrew Leslie, Group Leader for structural studies of macromolecular complexes within the Division of Structural Studies, commented, "I'm personally delighted that we are getting the 50th system, congratulations to all concerned!"
As the world's first commercial robotic system for automated crystal sample mounting and storage, ACTOR eliminates much of the physical handling of samples by crystallographers required during routine screening and data collection either in the lab or at the beamline. It is an automated system designed to store frozen protein crystals, mount them sequentially, align them to the X-ray beam, collect complete data sets, and return the crystals to storage.
The ACTOR automated crystal mounting and data collection technology was co-developed by Rigaku with Oceaneering Space Systems (OSS), a division of Oceaneering International, Inc., under a license from Abbott® Laboratories for the purpose of offering a commercial high-throughput crystallography automation system. Astex™ Therapeutics Ltd. (Cambridge, UK) purchased the first ACTOR system in 20011. In 2002, the Rigaku ACTOR was honored with an R&D 100 Award for technical innovation. In 2005, Rigaku introduced a version of robot for small molecule chemical crystallography called the ACTOR SM.
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ACTOR
Rigaku CorporationACTOR™ (Automated crystal transport orientation and retrieval robot) is a proven commercial solution for automating routine crystal screening and data collection at both synchrotron beam lines and home laboratories. Compatible with almost any goniometer and detector combination, the ACTOR eliminates much of the physical handling of samples required during crystal screening and data collection. ACTOR allows you to screen up to 30 samples per hour. Adding automation to your structure solution pipeline also complements the high throughput needed for fragment based screening projects and structural genomics programs. ACTOR enables you to quickly screen many crystals for optimal diffraction qualities and cryo-conditions and includes ranking software to assist you in comparing samples and finding the best crystals for data collection.ACTOR allows you to effectively shorten the time gap between crystallization and structure solution. ACTOR was the first commercial automated crystal mounting robot and won the 2002 R&D 100 Award for technical innovation. Today over 60 ACTOR robots are in operation in home labs and at beamlines around the world. ACTOR can increase the number and quality of your diffraction experiments, ensuring your success in increasingly competitive funding and IP environments.ACTOR Features: Completely automated sample mounting, centering and data collection Integrated sample ranking and data collection strategy algorithms. Choice of dewar base plates for use with either ACTOR, ALS, Uni-Puck sample holders. (Tools and magazines for ALS and Uni-Puck must be purchased separately.) Storage capacity up to 240 samples: 3 Dewars with 80 sample capacity per dewar for ALS and UniPuck (Alternatively, 3 dewars with 60 sample capacity per dewar for ACTOR pucks or 3 dewars with 40 sample capacity per dewar for ESRF magazines)