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How to Improve Loading for Impurity Profiling of Basic Compounds using the Kinetex PS C18 HPLC/UHPLC Column

19 Jul 2019

In this application note, discover how the Kinetex PS C18 selectivity is particularly applicable for the analysis of polar basic compounds that contain basic functionality and typically exhibit poor selectivity/peak performance on traditional C18 phases.

Kinetex 2.6 µm PS C18

Phenomenex Inc

The new Kinetex 2.6 µm PS C18 phase is beneficial for all types of compounds (acids, bases, neutrals), but especially for the analysis of polar basic compounds. The phase has demonstrated increased polar analyte retention, improved peak shape for troublesome basic analytes under typical reversed phase conditions, and a unique multi-modal interaction selectivity making it indispensable tool for multi-compound and metabolite profile screens.

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How to Improve Loading for Impurity Profiling of Basic Compounds using the Kinetex PS C18 HPLC/UHPLC Column